Corrado O J, Gould C A, Kassab J Y, Davies R J
Thorax. 1986 Nov;41(11):863-8. doi: 10.1136/thx.41.11.863.
The nasal responses to provocation with histamine and methacholine were compared in 20 subjects with and 20 without rhinitis. Two variables were measured: nasal airways resistance and the development of rhinorrhoea. Histamine had a greater effect than methacholine in increasing nasal airways resistance while the converse was true for rhinorrhoea. Rhinitic subjects had a significantly greater response to histamine induced changes in nasal airways resistance (p less than 0.05), rhinorrhoea (p less than 0.05) and methacholine induced rhinorrhoea (p less than 0.01) than those without rhinitis. No significant differences were found between the two groups in methacholine induced changes in nasal airways resistance. The findings show that, like the lower airways of patients with asthma, the nasal mucosa of rhinitic subjects shows a greater responsiveness to non-specific agonists than that of non-rhinitic subjects.
在20名有鼻炎和20名无鼻炎的受试者中比较了组胺和乙酰甲胆碱激发试验的鼻腔反应。测量了两个变量：鼻气道阻力和鼻漏的发生情况。组胺在增加鼻气道阻力方面比乙酰甲胆碱有更大的作用，而在鼻漏方面则相反。与无鼻炎的受试者相比，鼻炎患者对组胺引起的鼻气道阻力变化（p<0.05）、鼻漏（p<0.05）和乙酰甲胆碱引起的鼻漏（p<0.01）有明显更大的反应。两组在乙酰甲胆碱引起的鼻气道阻力变化方面未发现显著差异。研究结果表明，与哮喘患者的下呼吸道一样，鼻炎患者的鼻黏膜对非特异性激动剂的反应性比非鼻炎患者更高。
