Delemarre-van de Waal H A
Tijdschr Kindergeneeskd. 1986 Dec;54(6):176-82.
Puberty is a maturational process of the hypothalamo-pituitary-gonadal axis resulting in growth and development of the genital organs and concomitantly physical changes. All these changes are the result of an increasing activity of the pituitary and consequently of the gonads caused by increased stimulation by the luteinizing hormone-releasing hormone (LHRH). Delayed puberty is a common problem in contrast to true hypogonadotropic hypogonadism. Since a few years pulsatile LHRH administration is applied to induce pubertal development in hypogonadotropic boys. Except for virilisation, development of the testes including spermatogenesis can be achieved. In contrast to boys, substitution with sex steroids brings about a satisfactory physiologic development of the sex characteristics in girls. The physiology and disorders of pubertal development as well as this new LHRH treatment to induce puberty will be discussed in this paper.
青春期是下丘脑 - 垂体 - 性腺轴的成熟过程，导致生殖器官生长发育并伴随身体变化。所有这些变化都是由促黄体生成激素释放激素（LHRH）刺激增加，从而导致垂体活动增强，进而性腺活动增强的结果。与真正的低促性腺激素性性腺功能减退相反，青春期延迟是一个常见问题。近年来，脉冲式LHRH给药已被用于诱导低促性腺激素性男孩的青春期发育。除了男性化外，还可以实现睾丸发育，包括精子发生。与男孩不同，用性类固醇替代可使女孩的性征得到令人满意的生理发育。本文将讨论青春期发育的生理学和紊乱情况以及这种诱导青春期的新LHRH治疗方法。
