Neurocenter of Southern Switzerland, EOC, Via Tesserete 46, 6900, Lugano, Switzerland.
Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Via Giuseppe Buffi 13, 6900, Lugano, Switzerland.
Sci Rep. 2022 Apr 27;12(1):6866. doi: 10.1038/s41598-022-10802-y.
Alterations in brain plasticity seem to play a role in the pathophysiology of cervical dystonia (CD). Since evidences indicate that sleep regulates brain plasticity, we hypothesized that an alteration in sleep homeostatic mechanisms may be involved in the pathogenesis of CD. We explored sleep in control subjects (CTL) and CD patients before (T) and after (T) botulinum toxin (BoNT) treatment. A physiological slow wave activity (SWA) power decrease throughout the night was observed in CTL but not in CD at T. BoNT restored the physiological SWA decrease in CD at T. Furthermore, in the first part of the night, CD at T showed a frontal increase and parietal decrease in SWA power compared to CD at T, with a SWA distribution comparable to that observed in CTL. Our data highlighted a pathophysiological relationship between SWA during sleep and CD and provided novel insight into the transient central plastic effect of BoNT.
大脑可塑性的改变似乎在颈性肌张力障碍 (CD) 的病理生理学中起作用。由于有证据表明睡眠调节大脑可塑性，我们假设睡眠内稳态机制的改变可能与 CD 的发病机制有关。我们在肉毒毒素 (BoNT) 治疗前 (T) 和治疗后 (T) 时，对对照组 (CTL) 和 CD 患者的睡眠进行了研究。在 CTL 中观察到整个晚上的生理慢波活动 (SWA) 功率下降，但在 T 时 CD 中未观察到。BoNT 在 T 时恢复了 CD 的生理 SWA 下降。此外，在夜间的前半部分，与 T 时的 CD 相比，T 时的 CD 在前额显示出 SWA 功率的增加和顶叶的减少，其 SWA 分布与 CTL 观察到的相似。我们的数据强调了睡眠期间 SWA 与 CD 之间的病理生理关系，并为 BoNT 的短暂中枢可塑性效应提供了新的见解。
