Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Department of Pathology, Brigham and Women's Hospital, Boston, MA.
Clin Lymphoma Myeloma Leuk. 2022 Sep;22(9):643-651. doi: 10.1016/j.clml.2022.03.008. Epub 2022 Mar 19.
The myeloid and/or lymphoid neoplasms with eosinophilia and gene rearrangement (MLN-Eos) are a rare group of hematopoietic neoplasms with diverse and often perplexing presentations that can cause challenges, and even potential pitfalls, for the diagnostic pathologist. However, accurate diagnosis of this group of disorders is of the utmost importance, since the presence of specific gene rearrangements dictates targeted patient therapy. The goal of this review is to discuss the current literature, including emergence of novel molecular data, and equip pathologists and clinicians with morphologic and immunophenotypic clues for diagnosing this challenging group of hematopoietic neoplasms.
伴嗜酸性粒细胞增多和基因重排的髓系和/或淋系肿瘤（MLN-Eos）是一组罕见的造血肿瘤，具有多样化且常常令人困惑的表现，这可能会给诊断病理学家带来挑战，甚至是潜在的陷阱。然而，准确诊断这类疾病至关重要，因为特定基因重排的存在决定了针对患者的靶向治疗。本综述的目的是讨论当前的文献，包括新的分子数据的出现，并为病理学家和临床医生配备用于诊断这组具有挑战性的造血肿瘤的形态学和免疫表型线索。
