肺癌放疗后生存的预后因素-吸烟包年数的影响。
Prognostic Factors of Survival After Radiotherapy for Lung Cancer-The Impact of Smoking Pack Years.
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Department of Pulmonology, University of Lübeck, Lübeck, Germany.
出版信息
In Vivo. 2022 May-Jun;36(3):1297-1301. doi: 10.21873/invivo.12830.
BACKGROUND/AIM: The prognostic role of smoking pack years after thoracic irradiation for lung cancer needs further clarification, since previous studies showed conflicting results. Therefore, this study investigated potential prognostic factors for survival including pack years in 170 lung cancer patients receiving local radiotherapy.
PATIENTS AND METHODS
Twelve factors were retrospectively evaluated for survival including age, sex, tumor site, histology, primary tumor stage, nodal stage, distant metastasis, radiation dose, upfront surgery or systemic treatment, pulmonary function, and number of pack years.
RESULTS
On univariate analyses, absence of distant metastasis (p=0.049), radiation dose >56 Gy (p=0.019), and ≤40 pack years (p=0.005) were significantly associated with better survival. In the multivariate analysis, number of pack years (hazard ratio 2.18, 95% confidence interval 1.25-3.82, p=0.006) maintained significance; distant metastasis (p=0.34) and radiation dose (p=0.16) were not significant.
CONCLUSION
Number of pack years was an independent predictor of survival after thoracic irradiation for lung cancer.
背景/目的：肺癌患者接受胸部放疗后吸烟包年数的预后作用仍需进一步阐明，因为先前的研究结果存在矛盾。因此，本研究调查了 170 例接受局部放疗的肺癌患者的生存相关潜在预后因素，包括吸烟包年数。
患者和方法
回顾性评估了 12 个因素与生存的关系，包括年龄、性别、肿瘤部位、组织学、原发肿瘤分期、淋巴结分期、远处转移、放疗剂量、术前手术或全身治疗、肺功能和吸烟包年数。
结果
单因素分析显示，无远处转移（p=0.049）、放疗剂量＞56Gy（p=0.019）和≤40 包年（p=0.005）与生存时间延长显著相关。多因素分析显示，吸烟包年数（风险比 2.18，95%置信区间 1.25-3.82，p=0.006）仍有统计学意义；远处转移（p=0.34）和放疗剂量（p=0.16）无统计学意义。
结论
吸烟包年数是肺癌患者接受胸部放疗后生存的独立预测因素。
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