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对称亚甲基二酯的无溶剂合成——芳族羧酸盐与1, -二卤代烷的直接反应

Solvent-free synthesis of symmetric methylene diesters direct reaction of aromatic carboxylates with 1,-dihaloalkanes.

作者信息

Bai Lin, Ding Shenglong, Ma Xiaofang

机构信息

Institute of Green Chemistry Experiment and Teaching, Lanzhou City University Lanzhou Gansu 730070 China

College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou Gansu 730000 China.

出版信息

RSC Adv. 2021 Aug 25;11(46):28711-28715. doi: 10.1039/d1ra04814g. eCollection 2021 Aug 23.

DOI:10.1039/d1ra04814g
PMID:35478540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9038108/
Abstract

An efficient methodology for the synthesis of symmetrical methylene diesters was developed through direct reaction of various aromatic carboxylates with 1,-dihaloalkanes under solvent-free conditions. This strategy offers a high product yield, facile work-up and purification, and an environmentally friendly approach to obtain long-chain methylene carboxylate scaffolds with increased diversity.

摘要

通过各种芳族羧酸盐与1，-二卤代烷在无溶剂条件下直接反应，开发了一种高效合成对称亚甲基二酯的方法。该策略具有高产物收率、易于后处理和纯化的特点，并且是一种获得具有增加多样性的长链亚甲基羧酸盐支架的环境友好方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41d0/9038108/6f26d075870b/d1ra04814g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41d0/9038108/ae9a53f2f9fa/d1ra04814g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41d0/9038108/6f26d075870b/d1ra04814g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41d0/9038108/ae9a53f2f9fa/d1ra04814g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41d0/9038108/6f26d075870b/d1ra04814g-s2.jpg

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本文引用的文献

1
Lewis-acid catalysis of photochemical reactions. 6. Selective isomerization of .beta.-furylacrylic and urocanic esters.光化学反应的路易斯酸催化作用。6. β-呋喃丙烯酸酯和尿刊酸酯的选择性异构化反应
J Am Chem Soc. 1986 Sep 1;108(19):5964-8. doi: 10.1021/ja00279a049.
2
Preparation of strained axially chiral (1,5)naphthalenophanes by photo-dehydro-Diels-Alder reaction.通过光去氢 Diels-Alder 反应制备受应变的轴向手性（1,5）萘烷。
J Am Chem Soc. 2011 Mar 2;133(8):2642-50. doi: 10.1021/ja109118m. Epub 2011 Feb 7.
3
Novel lipophilic 7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivatives as potential antitumor agents: improved synthesis and in vitro evaluation.
新型亲脂性 7H-吡啶并[1,2,3-de]-1,4-苯并恶嗪-6-羧酸衍生物作为潜在的抗肿瘤药物：改进的合成及体外评价。
Bioorg Med Chem. 2010 Dec 15;18(24):8537-48. doi: 10.1016/j.bmc.2010.10.039. Epub 2010 Oct 20.
4
(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.作为新型一氧化氮释放阿司匹林的（硝基氧酰氧基）甲酯。
J Med Chem. 2009 Aug 27;52(16):5058-68. doi: 10.1021/jm900587h.
5
The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters.细胞内释放的甲醛和丁酸在酰氧基烷基酯抗癌活性中的作用。
J Med Chem. 2005 Feb 24;48(4):1042-54. doi: 10.1021/jm049428p.
6
Selective Diesterification of Diols through Cyclic Ketene Acetal Intermediates.通过环状乙烯酮缩醛中间体对二醇进行选择性二酯化反应。
J Org Chem. 1999 Oct 29;64(22):8386-8395. doi: 10.1021/jo990227g.
7
Tranexamic acid derivatives with enhanced absorption.
J Med Chem. 1986 Apr;29(4):448-53. doi: 10.1021/jm00154a004.