State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Chongqing Key Laboratory for Disease Proteomics, Chongqing, China.
Front Immunol. 2022 Apr 11;13:875076. doi: 10.3389/fimmu.2022.875076. eCollection 2022.
For the skin immune system, γδ T cells are important components, which help in defensing against damage and infection of skin. Compared to the conventional αβ T cells, γδ T cells have their own differentiation, development and activation characteristics. In adult mice, dendritic epidermal T cells (DETCs), Vγ4 and Vγ6 γδ T cells are the main subsets of skin, the coordination and interaction among them play a crucial role in wound repair. To get a clear overview of γδ T cells, this review synopsizes their derivation, development, colonization and activation, and focuses their function in acute and chronic wound healing, as well as the underlining mechanism. The aim of this paper is to provide cues for the study of human epidermal γδ T cells and the potential treatment for skin rehabilitation.
对于皮肤免疫系统，γδ T 细胞是重要的组成部分，有助于防御皮肤的损伤和感染。与传统的 αβ T 细胞相比，γδ T 细胞具有自身的分化、发育和激活特征。在成年小鼠中，树突状表皮 T 细胞（DETCs）、Vγ4 和 Vγ6 γδ T 细胞是皮肤的主要亚群，它们之间的协调和相互作用在伤口修复中起着至关重要的作用。为了更全面地了解 γδ T 细胞，本综述总结了它们的起源、发育、定植和激活，并重点介绍了它们在急性和慢性伤口愈合中的功能以及潜在的作用机制。本文旨在为人类表皮 γδ T 细胞的研究和皮肤康复的潜在治疗提供线索。
