Thushara Nadini, Darshani Taniya, Samarakoon Sameera R, Perera Inoka C, Fronczek Frank R, Sameera W M C, Perera Theshini
Department of Chemistry, University of Sri Jayewardenepura Sri Lanka
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo Sri Lanka.
RSC Adv. 2021 May 14;11(29):17658-17668. doi: 10.1039/d1ra00842k. eCollection 2021 May 13.
Three new Pt complexes, [PtCl(N(SO(2-nap))dpa)], [PtCl(N(SO(1-nap))dpa)] and [PtCl(N(SOpip)dpa)], containing a rare 8-membered ring were synthesized in good yield and high purity by utilizing the ligands N(SO(2-nap))dpa, N(SO(1-nap))dpa and N(SOpip)dpa, which contain a dipicolylamine moiety. Structural studies of all three complexes confirmed that the ligands are bound in a bidentate mode Pt-N bonds forming a rare 8-membered ring. The intense fluorescence displayed by the ligands is quenched upon coordination to Pt. According to time dependent density functional theory (TDDFT) calculations, the key excitations of N(SO(2-nap))dpa and [PtCl(N(SO(1-nap))dpa)] involve the 2-nap-ligand-centered π → π* excitations. While all six compounds have shown antiproliferative activity against human breast cancer cells (MCF-7), the N(SOpip)dpa and N(SO(2-nap))dpa ligands and [PtCl((NSOpip)dpa)] complex have shown significantly high cytotoxicity, directing them to be further investigated as potential anti-cancer drug leads.
利用含有二吡啶甲胺部分的配体N(SO(2 - nap))dpa、N(SO(1 - nap))dpa和N(SOpip)dpa，以良好的产率和高纯度合成了三种新的含有罕见八元环的铂配合物[PtCl(N(SO(2 - nap))dpa)]、[PtCl(N(SO(1 - nap))dpa)]和[PtCl(N(SOpip)dpa)]。对这三种配合物的结构研究证实，配体以双齿模式结合，Pt - N键形成一个罕见的八元环。配体显示的强烈荧光在与铂配位时被猝灭。根据含时密度泛函理论(TDDFT)计算，N(SO(2 - nap))dpa和[PtCl(N(SO(1 - nap))dpa)]的关键激发涉及2 - nap - 配体中心的π → π*激发。虽然所有六种化合物都对人乳腺癌细胞(MCF - 7)显示出抗增殖活性，但N(SOpip)dpa和N(SO(2 - nap))dpa配体以及[PtCl((NSOpip)dpa)]配合物显示出显著的高细胞毒性，这使得它们作为潜在的抗癌药物先导物有待进一步研究。
