Thada Is Dispensable for Female Fertility in Mice.

Genome-wide association studies (GWAS) have identified as one of the susceptibility genes for polycystic ovary syndrome (PCOS). Single nucleotide polymorphisms (SNPs) in the gene showed significant over-transmission in PCOS and strong correlations with testosterone level. However, there was insufficient evidence to verify the effect of on female reproductive system. In this study, we investigated the impacts of ablation on ovarian function and reproductive outcomes with knockout (KO) mice. The results showed that the deletion was insufficient to affect ovarian folliculogenesis, steroidogenesis, and female fertility. Additionally, we stressed the mice with high-fat-high-sugar diet (HFHS). In this case, the KO mice still merely had a negligible impact on ovarian function. These findings indicated that deficiency was dispensable for female fertility in mice, which enriched our knowledge about functions of PCOS susceptibility genes.