重症肌无力合并甲状腺功能亢进症的临床特征分析
Analysis of clinical features of myasthenia gravis complicated with hyperthyroidism.
作者信息
Wang Yaxuan, Qi Guoyan, Yang Ying
机构信息
Yaxuan Wang, Center of Treatment of Myasthenia Gravis Hebei Province, Shi Jiazhuang People's Hospital, Shi Jiazhuang, 050000, Hebei, China.
Guoyan Qi, Center of Treatment of Myasthenia Gravis Hebei Province, Shi Jiazhuang People's Hospital, Shi Jiazhuang, 050000, Hebei, China.
出版信息
Pak J Med Sci. 2022 Mar-Apr;38(3Part-I):530-535. doi: 10.12669/pjms.38.3.4656.
OBJECTIVES
To investigate the clinical features of patients with myasthenia gravis complicated with and without hyperthyroidism.
METHODS
A total of 2083 patients with myasthenia gravis (MG) admitted in Center of Treatment of Myasthenia Gravis Hebei Province between January 2013 and July 2020 were retrospectively analyzed and divided into two groups: Group-A and Group-B, with 108 MG patients complicated with hyperthyroidism in Group-A and 1975 MG patients without thyroid disease in Group-B. The age of onset, gender, Osserman classification, acetylcholine receptor antibody and thymus status of the two groups were analyzed in the two groups. Independent-sample t test was used for intra-group comparison, and χ2 test was utilized for comparison of enumeration data. P<0.05 indicates a statistically significant difference.
RESULTS
The age of onset in Group-A was significantly lower than that in Group-B (p=0.000), the number of female patients was significantly higher than that in Group-B (p=0.037), and the level of Achrabs titer was significantly lower than that in Group-B (p=0.000). The incidence of thymoma in Group-A was significantly lower than that in Group-B (p=0.012), while the incidence of thymic hyperplasia was significantly higher than that in Group-B (p=0.000).
CONCLUSION
Patients with MG complicated with hyperthyroidism are mainly female, with a lower age of onset, a lower level of acetylcholine receptor antibody, a lower incidence of thymoma, and a higher incidence of thymic hyperplasia. The clinical features of such patients are remarkably different from those of MG without thyroid disease.
目的
探讨合并和未合并甲状腺功能亢进的重症肌无力患者的临床特征。
方法
回顾性分析2013年1月至2020年7月在河北省重症肌无力治疗中心收治的2083例重症肌无力（MG）患者，分为A组和B组，A组为108例合并甲状腺功能亢进的MG患者，B组为1975例无甲状腺疾病的MG患者。分析两组患者的发病年龄、性别、Osserman分型、乙酰胆碱受体抗体及胸腺状态。组内比较采用独立样本t检验，计数资料比较采用χ2检验。P<0.05表示差异有统计学意义。
结果
A组发病年龄显著低于B组（p=0.000），女性患者数量显著高于B组（p=0.037），Achrabs滴度水平显著低于B组（p=0.000）。A组胸腺瘤发生率显著低于B组（p=0.012），而胸腺增生发生率显著高于B组（p=0.000）。
结论
合并甲状腺功能亢进的MG患者以女性为主，发病年龄较低，乙酰胆碱受体抗体水平较低，胸腺瘤发生率较低，胸腺增生发生率较高。此类患者的临床特征与无甲状腺疾病的MG患者明显不同。
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