Department of Neurology, The First Affiliated Hospital, Sun Yat-sen Uni, 58 Zhongshan 2nd Road, Guangzhou 510080, China.
Neurol Sci. 2013 Jun;34(6):911-7. doi: 10.1007/s10072-012-1157-z. Epub 2012 Jul 18.
The objectives of the study are to study the clinical features of myasthenia gravis in southern China. A retrospective study was carried out on all patients who were diagnosed with myasthenia gravis at the First Affiliated Hospital of Sun Yat-sen University during 1987-2009. Of the 2,154 myasthenia gravis patients, the gender ratio (male:female) was 1:1.15. The median age at onset was 18 years. There was a single peak distribution of age at onset, and 44.8 % were children (≤ 14 years) at first onset. 1,766 patients (82.0 %) only had ocular symptoms at onset. 1,451 patients (67.4 %) were classified as Osserman grade I. 250 unselected patients received anti-acetylcholine receptor antibodies test, in which only 51.2 % were positive. Computed tomography scan/magnetic resonance Imaging of chest were done in 1,354 patients, of which 899 patients (66.4 %) had thymic hyperplasia and 201(14.8 %) had thymoma. There were 150 patients (7.0 %) with myasthenia gravis combined with other autoimmune diseases, in which hyperthyroidism was most common (84 %). 189 (8.8 %) patients experienced 267 episodes of crisis. The rate of family myasthenia gravis was 1.6 % (35/2,154). In conclusion, the clinical features and demography of myasthenia gravis patients in this study are significantly different from prior studies on other regions and ethnic groups.
本研究旨在探讨中国南方地区重症肌无力的临床特征。我们对 1987 年至 2009 年期间在中山大学附属第一医院被诊断为重症肌无力的所有患者进行了回顾性研究。在 2154 例重症肌无力患者中，男女比例为 1:1.15。发病中位年龄为 18 岁。发病年龄呈单峰分布，44.8%的患者首次发病时为儿童（≤14 岁）。1766 例（82.0%）患者发病时仅有眼肌症状。1451 例（67.4%）患者被分类为 Osserman Ⅰ级。250 例未经选择的患者接受了抗乙酰胆碱受体抗体检测，其中仅 51.2%为阳性。对 1354 例患者进行了胸部计算机断层扫描/磁共振成像检查，其中 899 例（66.4%）患者胸腺增生，201 例（14.8%）患者患有胸腺瘤。有 150 例（7.0%）重症肌无力患者合并其他自身免疫性疾病，其中最常见的是甲状腺功能亢进（84%）。189 例（8.8%）患者发生了 267 次危象。家族性重症肌无力的发生率为 1.6%（35/2154）。总之，本研究中重症肌无力患者的临床特征和人口统计学特征与其他地区和种族的研究有显著差异。
