苯并(a)芘暴露与 AhR 信号通路遗传多态性对稽留流产的交互作用。
Interactions between Benzo(a)pyrene exposure and genetic polymorphisms of AhR signaling pathway on missed abortion.
机构信息
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Obstetrics, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
出版信息
Int J Environ Health Res. 2023 Sep;33(9):881-893. doi: 10.1080/09603123.2022.2064436. Epub 2022 Apr 28.
Benzo(a)pyrene (BaP) is an environmental pollutant widely exposed to human beings. While the relationship between BaP and missed abortion is few understood. To explore the association between missed abortion and BaP, genetic polymorphisms of AhR pathway, we recruited 112 cases women with missed abortion and 137 controls women with normal pregnancy from Shanxi, China. The BPDE-DNA adducts level in the case group was higher than that in the control group ( < 0.001). The subjects were categorized according to the tertiles of BPDE-DNA adduct concentrations: T (<), T (~) and T (≥), the results suggested that the risk of missed abortion at T and T levels were 5.68 times ( = 0.009), 6.17 times ( = 0.001) higher than that of T level, respectively. The interaction between ALDH3A1 rs887241 and BPDE-DNA adducts was indicated. These findings show that BaP exposure may affect the risk of missed abortion, and genetic polymorphisms may change the susceptibility to BaP.
苯并(a)芘（BaP）是一种广泛存在于人类环境中的污染物。尽管 BaP 与自然流产的关系尚未完全阐明，但我们仍试图探究 BaP 暴露与自然流产之间的关联，以及芳香烃受体（AhR）通路的遗传多态性。为此，我们招募了 112 例自然流产患者和 137 例正常妊娠对照来自中国山西。结果发现，病例组 BPDE-DNA 加合物水平高于对照组（<0.001）。根据 BPDE-DNA 加合物浓度的三分位进行分组：T（<）、T（~）和 T（≥）。结果显示，T 和 T 水平的自然流产风险分别是 T 水平的 5.68 倍（=0.009）和 6.17 倍（=0.001）。此外，还发现 ALDH3A1 rs887241 与 BPDE-DNA 加合物之间存在交互作用。综上所述，BaP 暴露可能会影响自然流产的发生风险，而遗传多态性可能会改变 BaP 的易感性。
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