卡立普嗪治疗首发精神病阴性症状：病例系列
Cariprazine as a treatment for negative psychotic symptoms in first-episode psychosis: case series.
作者信息
Demjaha Arsime, Iacoponi Eduardo, Hansen Lars, Peddu Pradeep, McGuire Philip
机构信息
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; and NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London, UK.
Lambeth Early Intervention Service, South London and Maudsley NHS Foundation Trust, UK.
出版信息
BJPsych Open. 2022 Apr 28;8(3):e88. doi: 10.1192/bjo.2022.56.
Negative psychotic symptoms are among the most disabling features of schizophrenia, and are strongly associated with relatively poor clinical and functional outcomes. However, there are no effective treatments for negative symptoms, and this represents a major unmet clinical need. Recent research has shown that negative symptoms are already present in many patients at illness onset. There is evidence that cariprazine may improve negative symptoms in patients with chronic schizophrenia. However, its utility in treating negative symptoms in the early stage of the disorder is unclear. Here, we report six cases of patients with first-episode psychosis who were treated with cariprazine.
阴性精神病性症状是精神分裂症最具致残性的特征之一，且与相对较差的临床和功能结局密切相关。然而，目前尚无针对阴性症状的有效治疗方法，这代表了一项重大的未满足的临床需求。最近的研究表明，许多患者在疾病发作时就已出现阴性症状。有证据表明，卡立普嗪可能改善慢性精神分裂症患者的阴性症状。然而，其在该疾病早期治疗阴性症状的效用尚不清楚。在此，我们报告6例接受卡立普嗪治疗的首发精神病患者的病例。
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