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半剂量光动力疗法治疗接受皮质类固醇治疗的 Behcet 葡萄膜炎患者的中心性浆液性脉络膜视网膜病变。

Half-fluence Photodynamic Therapy for Central Serous Chorioretinopathy in a Patient Receiving Corticosteroids for Behçet's Uveitis.

机构信息

Gazi University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

University of Health Sciences Turkey, Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Turkey

出版信息

Turk J Ophthalmol. 2022 Apr 28;52(2):142-146. doi: 10.4274/tjo.galenos.2022.96461.

Abstract

Corticosteroid-induced central serous chorioretinopathy (CSCR) has been reported to develop in many intraocular inflammatory diseases and usually resolves spontaneously after discontinuation of corticosteroids. Patients without any improvement may require alternative therapies. In this case report, we present the case of a 35-year-old man with Behçet's disease who had complaints of decreased vision due to CSCR in his left eye while using systemic corticosteroids along with cyclosporine and azathioprine. Half-fluence photodynamic therapy (PDT) was performed because the CSCR did not regress despite discontinuation of systemic corticosteroids. After treatment, his visual acuity increased with complete resolution of the subfoveal fluid. Half-fluence PDT seems to be an effective and safe treatment for patients who develop acute CSCR while under systemic or local corticosteroid therapy for intraocular inflammatory diseases such as Behçet's uveitis and do not improve despite steroid discontinuation.

摘要

皮质类固醇诱导的中心性浆液性脉络膜视网膜病变(CSCR)已在许多眼内炎症性疾病中报道,通常在停用皮质类固醇后会自发消退。没有任何改善的患者可能需要替代疗法。在本病例报告中,我们介绍了一名 35 岁男性的病例,他患有贝切特病,在使用环孢素和硫唑嘌呤的同时全身使用皮质类固醇,左眼出现 CSCR,视力下降。尽管停用全身皮质类固醇,但 CSCR 仍未消退,因此进行了半剂量光动力疗法(PDT)。治疗后,他的视力提高,黄斑下积液完全消退。对于在眼内炎症性疾病(如贝切特葡萄膜炎)中接受全身或局部皮质类固醇治疗时发生急性 CSCR 且尽管停用类固醇仍未改善的患者,半剂量 PDT 似乎是一种有效且安全的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd31/9069094/9244770074a7/TJO-52-142-g1.jpg

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