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乳房库珀韧带的实验特性分析与建模。

Experimental characterisation and modelling of breast Cooper's ligaments.

机构信息

University of Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000, Grenoble, France.

Laboratoire d'Anatomie des Alpes Française, Faculté de Médecine, Domaine de la Merci, 38700, La Tronche Cedex, France.

出版信息

Biomech Model Mechanobiol. 2022 Aug;21(4):1157-1168. doi: 10.1007/s10237-022-01582-5. Epub 2022 Apr 28.

Abstract

The aim of this study was to characterise the mechanical behaviour of Cooper's ligaments. Such ligaments are collagenous breast tissue that create a three-dimensional structure over the entire breast volume. Ten ligaments were extracted from a human cadaver, from which 28 samples were cut and used to perform uniaxial tensile tests. Histological analysis showed that the main direction of the fibres visible to the naked eye corresponds to the orientation of the fibres on a microscopic scale. The specimens were cut according to this orientation, which allowed the sample to be stretched in the main fibre direction. From these experimental stretch/stress curves, an original anisotropic hyperelastic constitutive law is proposed to model the behaviour of Cooper's ligaments and the material parameter validity is discussed.

摘要

本研究旨在描述库珀韧带的力学特性。库珀韧带是一种胶原性乳房组织,在整个乳房体积上形成三维结构。从一个人体尸体中提取了 10 条韧带,从每条韧带中切下 28 个样本用于进行单轴拉伸试验。组织学分析表明,肉眼可见纤维的主要方向与微观尺度上纤维的方向相对应。根据该方向切割标本,使样品能够沿主要纤维方向拉伸。从这些实验的拉伸/应力曲线中,提出了一种原始各向异性超弹性本构律来模拟库珀韧带的行为,并讨论了材料参数的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bb7/9047630/116a3e2a18b5/10237_2022_1582_Fig1_HTML.jpg

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