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YAP: a novel target for Alzheimer's disease.

作者信息

Xu Xingxing, Wang Ying, Huang Zhihui

机构信息

School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.

Clinical Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

出版信息

Aging (Albany NY). 2022 Apr 28;14(9):3724-3725. doi: 10.18632/aging.204045.

DOI:10.18632/aging.204045
PMID:35482299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9134940/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e17f/9134940/7b6f4aea6f19/aging-14-204045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e17f/9134940/7b6f4aea6f19/aging-14-204045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e17f/9134940/7b6f4aea6f19/aging-14-204045-g001.jpg

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YAP: a novel target for Alzheimer's disease.YAP：阿尔茨海默病的一个新靶点。
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YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling.YAP 通过调节 CDK6 信号来防止星形胶质细胞的早衰和阿尔茨海默病的认知能力下降。
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Astrocyte senescence as a component of Alzheimer's disease.星形胶质细胞衰老作为阿尔茨海默病的一个组成部分。
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Astrocyte senescence promotes glutamate toxicity in cortical neurons.星形胶质细胞衰老促进皮质神经元谷氨酸毒性。
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Cellular senescence at the crossroads of inflammation and Alzheimer's disease.细胞衰老处于炎症和阿尔茨海默病的十字路口。
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引用本文的文献

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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer's disease.跨人类和3D细胞模型的综合通路分析确定p38丝裂原活化蛋白激酶-MK2轴为阿尔茨海默病的治疗靶点。
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Mechanical confinement matters: Unveiling the effect of two-photon polymerized 2.5D and 3D microarchitectures on neuronal YAP expression and neurite outgrowth.机械限制至关重要：揭示双光子聚合的2.5D和3D微结构对神经元YAP表达和神经突生长的影响。
Mater Today Bio. 2024 Nov 2;29:101325. doi: 10.1016/j.mtbio.2024.101325. eCollection 2024 Dec.
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本文引用的文献

1
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling.YAP 通过调节 CDK6 信号来防止星形胶质细胞的早衰和阿尔茨海默病的认知能力下降。
Aging Cell. 2021 Sep;20(9):e13465. doi: 10.1111/acel.13465. Epub 2021 Aug 20.
2
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.D-半乳糖通过YAP-CDK6信号通路诱导胶质母细胞瘤细胞衰老。
Aging (Albany NY). 2020 Sep 29;12(18):18501-18521. doi: 10.18632/aging.103819.
3
Astrocyte Senescence and Alzheimer's Disease: A Review.
Extract Improves the Cognitive Deficits and Reverses the Pathological Changes of Alzheimer's Disease via Regulating YAP Signaling.
提取物通过调节 YAP 信号改善阿尔茨海默病的认知缺陷并逆转其病变。
Int J Mol Sci. 2023 Mar 9;24(6):5259. doi: 10.3390/ijms24065259.
星形胶质细胞衰老与阿尔茨海默病：综述
Front Aging Neurosci. 2020 Jun 9;12:148. doi: 10.3389/fnagi.2020.00148. eCollection 2020.
4
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.YAP 依赖性细胞坏死发生在阿尔茨海默病的早期阶段，并调节小鼠模型的病理学。
Nat Commun. 2020 Jan 24;11(1):507. doi: 10.1038/s41467-020-14353-6.
5
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.清除衰老的神经胶质细胞可预防tau 依赖性病变和认知能力下降。
Nature. 2018 Oct;562(7728):578-582. doi: 10.1038/s41586-018-0543-y. Epub 2018 Sep 19.
6
p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration.p53 异构体调节星形胶质细胞介导的神经保护和神经退行性变。
Cell Death Differ. 2016 Sep 1;23(9):1515-28. doi: 10.1038/cdd.2016.37. Epub 2016 Apr 22.
7
YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis.YAP是SOCS3的关键诱导因子，可预防反应性星形胶质细胞增生。
Cereb Cortex. 2016 May;26(5):2299-2310. doi: 10.1093/cercor/bhv292. Epub 2015 Dec 17.
8
Astrocyte senescence as a component of Alzheimer's disease.星形胶质细胞衰老作为阿尔茨海默病的一个组成部分。
PLoS One. 2012;7(9):e45069. doi: 10.1371/journal.pone.0045069. Epub 2012 Sep 12.