Silbergeld E K, Mattison D R
Am J Ind Med. 1987;11(2):131-44. doi: 10.1002/ajim.4700110203.
The reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been studied in animal models and in human populations. In animals, TCDD has a range of toxic effects on organs of the reproductive system in males and females, on hormone biochemistry, and on embryo-fetal development. These effects may involve in part an identified intracellular TCDD receptor and its association with the induction of microsomal cytochrome P-450-dependent monooxygenases in many organs. TCDD treatment increases activity of monooxygenase enzyme in liver and gonads of treated animals, but unlike other polycyclic aromatic hydrocarbons that are monooxygenase inducers, TCDD is not cytotoxic to any population of oocytes in the mature female mouse. Epidemiological studies of TCDD reproductive toxicity have been limited in design. There are some reports of adverse effects in the Seveso population and in children born to American veterans presumed to have been exposed to TCDD in Agent Orange during the Vietnam war. Occupational cohorts have not been found to show such paternally mediated effects of TCDD exposure.
2,3,7,8-四氯二苯并对二恶英（TCDD）的生殖毒理学已在动物模型和人类群体中进行了研究。在动物中，TCDD对雄性和雌性生殖系统的器官、激素生物化学以及胚胎-胎儿发育具有一系列毒性作用。这些作用可能部分涉及一种已确定的细胞内TCDD受体及其与许多器官中微粒体细胞色素P-450依赖性单加氧酶诱导的关联。TCDD处理可增加处理动物肝脏和性腺中单加氧酶的活性，但与其他作为单加氧酶诱导剂的多环芳烃不同，TCDD对成熟雌性小鼠的任何卵母细胞群体均无细胞毒性。TCDD生殖毒性的流行病学研究在设计上受到限制。有一些关于塞韦索人群以及据推测在越南战争期间接触过橙剂中TCDD的美国退伍军人所生孩子出现不良反应的报告。尚未发现职业队列显示出TCDD暴露的这种父系介导效应。
