Zhang Yijian, Liu Tao, Yang Huilin, He Fan, Zhu Xuesong
Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China.
Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China.
Ageing Res Rev. 2022 Jun;78:101635. doi: 10.1016/j.arr.2022.101635. Epub 2022 Apr 25.
Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and subchondral bone remodeling, is a common joint degenerative disease worldwide. OA pathogenesis is regulated by multiple predisposing factors, including imbalanced matrix metabolism, aberrant inflammatory response, and excessive oxidative stress. Moreover, melatonin has been implicated in development of several degenerative disorders owing to its potent biological functions. With regards to OA, melatonin reportedly promotes synthesis of cartilage matrix, inhibition of chondrocyte apoptosis, attenuation of inflammatory response, and suppression of matrix degradation by regulating the TGF-β, MAPK, or NF-κB signaling pathways. Notably, melatonin has been associated with amelioration of oxidative damage by restoring the OA-impaired intracellular antioxidant defense system in articular cartilage. Findings from preliminary application of melatonin or melatonin-loaded biomaterials in animal models have affirmed its potential anti-arthritic effects. Herein, we summarize the anti-arthritic effects of melatonin on OA cartilage and demonstrate that melatonin has potential therapeutic efficacy in treating OA.
骨关节炎（OA）是一种常见的全球关节退行性疾病，其特征为软骨侵蚀、滑膜炎症和软骨下骨重塑。OA的发病机制受多种易感因素调控，包括基质代谢失衡、异常炎症反应和过度氧化应激。此外，褪黑素因其强大的生物学功能，与多种退行性疾病的发生有关。关于OA，据报道褪黑素可通过调节TGF-β、MAPK或NF-κB信号通路促进软骨基质合成、抑制软骨细胞凋亡、减轻炎症反应并抑制基质降解。值得注意的是，褪黑素通过恢复OA受损的关节软骨细胞内抗氧化防御系统，与氧化损伤的改善有关。褪黑素或载有褪黑素的生物材料在动物模型中的初步应用结果证实了其潜在的抗关节炎作用。在此，我们总结了褪黑素对OA软骨的抗关节炎作用，并证明褪黑素在治疗OA方面具有潜在的治疗效果。
