Hollander D I, Nagey D A, Pupkin M J
Am J Obstet Gynecol. 1987 Mar;156(3):631-7. doi: 10.1016/0002-9378(87)90066-4.
The efficacy of magnesium sulfate was analyzed in relation to ritodrine hydrochloride. Patients presenting in preterm labor between 20 and 35 weeks' gestation were prospectively randomized. Tocolysis was achieved for more than 72 hours in 35 of 40 cases (88%) where magnesium sulfate was administered and 31 of 39 cases (79%) in which ritodrine hydrochloride was infused. Delay of greater than or equal to 7 days was achieved in 75% and 72% of cases, respectively. The mean dosage to achieve tocolysis was 4.5 gm/hr, in the magnesium sulfate group and 210.0 micrograms/hr in ritodrine hydrochloride-treated patients. The mean magnesium level to achieve tocolysis was 6.60 mg/dl. Side effects in the two groups were similar in number but less alarming in the magnesium sulfate group. Magnesium sulfate was found to be easy to administer and clinically efficacious. Its tocolytic action was found to be dose dependent and drug concentrations are easily determined. On the basis of this work and data from other investigators, magnesium sulfate should be used as the first line of tocolytic therapy with ritodrine hydrochloride as its pharmacologic backup.
对硫酸镁与盐酸利托君的疗效进行了分析。对妊娠20至35周出现早产的患者进行前瞻性随机分组。在使用硫酸镁的40例患者中有35例（88%）实现了超过72小时的宫缩抑制，在输注盐酸利托君的39例患者中有31例（79%）实现了超过72小时的宫缩抑制。分别有75%和72%的病例实现了大于或等于7天的延迟。硫酸镁组实现宫缩抑制的平均剂量为4.5克/小时，盐酸利托君治疗组为210.0微克/小时。实现宫缩抑制的平均镁水平为6.60毫克/分升。两组的副作用数量相似，但硫酸镁组的副作用不那么令人担忧。发现硫酸镁易于给药且临床有效。发现其宫缩抑制作用具有剂量依赖性，且药物浓度易于测定。基于这项工作以及其他研究者的数据，硫酸镁应作为宫缩抑制治疗的一线用药，盐酸利托君作为其药理学备用药物。
