• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SARS-CoV-2 immunogenicity: Is S protein the best target for vaccination?

作者信息

Antonopoulou Tania, Athanassakis Irene

机构信息

Laboratory of Immunology, Department of Biology, University of Crete, Heraklion 70013, Crete, Greece.

Laboratory of Immunology, Department of Biology, University of Crete, Heraklion 70013, Crete, Greece; Immune Recognition PCC, Heraklion 71500, Crete, Greece.

出版信息

Vaccine. 2022 May 20;40(23):3093-3095. doi: 10.1016/j.vaccine.2022.04.061. Epub 2022 Apr 22.

DOI:10.1016/j.vaccine.2022.04.061
PMID:35484041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9023356/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6c/9023356/dba87339e5ad/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6c/9023356/dba87339e5ad/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6c/9023356/dba87339e5ad/gr1_lrg.jpg

相似文献

1
SARS-CoV-2 immunogenicity: Is S protein the best target for vaccination?严重急性呼吸综合征冠状病毒2型免疫原性：刺突蛋白是疫苗接种的最佳靶点吗？
Vaccine. 2022 May 20;40(23):3093-3095. doi: 10.1016/j.vaccine.2022.04.061. Epub 2022 Apr 22.
2
Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial.一种雾化型腺病毒 5 型载体新冠疫苗（Ad5-nCoV）在成年人中的安全性、耐受性和免疫原性：一项开放标签、随机 1 期临床试验的初步报告。
Lancet Infect Dis. 2021 Dec;21(12):1654-1664. doi: 10.1016/S1473-3099(21)00396-0. Epub 2021 Jul 26.
3
Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial.新型冠状病毒 ARCoV mRNA 疫苗在中国成年人中的安全性和免疫原性：一项随机、双盲、安慰剂对照、1 期临床试验。
Lancet Microbe. 2022 Mar;3(3):e193-e202. doi: 10.1016/S2666-5247(21)00280-9. Epub 2022 Jan 24.
4
Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting.在真实环境中评估灭活 COVID-19 疫苗诱导的 SARS-CoV-2 特异性体液和细胞免疫应答的特征。
Front Immunol. 2021 Dec 22;12:802858. doi: 10.3389/fimmu.2021.802858. eCollection 2021.
5
Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis.慢性透析患者 COVID-19 疫苗接种的免疫原性。
Front Immunol. 2021 Jun 30;12:690698. doi: 10.3389/fimmu.2021.690698. eCollection 2021.
6
The Safety and Immunogenicity of the mRNA-BNT162b2 SARS-CoV-2 Vaccine in Hemodialysis Patients.mRNA-1273 新冠病毒疫苗在血液透析患者中的安全性和免疫原性。
Front Immunol. 2021 Jun 16;12:704773. doi: 10.3389/fimmu.2021.704773. eCollection 2021.
7
Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers.疫苗类型和既往 SARS-CoV-2 感染与医护人员接种疫苗后症状和抗体测量的关联。
JAMA Intern Med. 2021 Dec 1;181(12):1660-1662. doi: 10.1001/jamainternmed.2021.4580.
8
A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge.一种基于人体细胞的 SARS-CoV-2 疫苗可引发强烈的中和抗体反应，并可保护小鼠免受 SARS-CoV-2 攻击。
Emerg Microbes Infect. 2021 Dec;10(1):1555-1573. doi: 10.1080/22221751.2021.1957400.
9
SARS-CoV-2 mRNA Vaccines Elicit Different Responses in Immunologically Naïve and Pre-Immune Humans.SARS-CoV-2 mRNA 疫苗在免疫原性初免和预免疫人群中引发不同的反应。
Front Immunol. 2021 Sep 27;12:728021. doi: 10.3389/fimmu.2021.728021. eCollection 2021.
10
Peritoneal Administration of a Subunit Vaccine Encapsulated in a Nanodelivery System Not Only Augments Systemic Responses against SARS-CoV-2 but Also Stimulates Responses in the Respiratory Tract.纳米递药系统包裹的亚单位疫苗经腹腔给药不仅增强了针对 SARS-CoV-2 的全身反应，还刺激了呼吸道的反应。
Viruses. 2021 Nov 2;13(11):2202. doi: 10.3390/v13112202.

引用本文的文献

1
DNA Vaccines: Their Formulations, Engineering and Delivery.DNA疫苗：其配方、工程设计与递送
Vaccines (Basel). 2024 Jan 11;12(1):71. doi: 10.3390/vaccines12010071.
2
Designing and Expression of Recombinant Chimeric Spike Protein from SARS-CoV-2 in and Its Immunogenicity Assessment.新型冠状病毒重组嵌合刺突蛋白的设计、表达及其免疫原性评估
Iran J Pharm Res. 2023 Sep 10;22(1):e137751. doi: 10.5812/ijpr-137751. eCollection 2023 Jan-Dec.

本文引用的文献

1
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19.SARS-CoV-2 刺突蛋白 S1 诱导纤维蛋白（原）抵抗纤维蛋白溶解：对 COVID-19 中小凝块形成的影响。
Biosci Rep. 2021 Aug 27;41(8). doi: 10.1042/BSR20210611.
2
High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages.早期人类抗SARS-CoV-2 IgG的高滴度和低岩藻糖基化通过肺泡巨噬细胞促进炎症。
Sci Transl Med. 2021 Jun 2;13(596). doi: 10.1126/scitranslmed.abf8654. Epub 2021 May 11.
3
Structural insights into SARS-CoV-2 proteins.
SARS-CoV-2 蛋白的结构见解。
J Mol Biol. 2021 Jan 22;433(2):166725. doi: 10.1016/j.jmb.2020.11.024. Epub 2020 Nov 24.
4
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition.SARS-CoV-2 衍生肽定义了异源和 COVID-19 诱导的 T 细胞识别。
Nat Immunol. 2021 Jan;22(1):74-85. doi: 10.1038/s41590-020-00808-x. Epub 2020 Sep 30.
5
Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition.分析 SARS-CoV-2 刺突蛋白糖罩揭示了对免疫识别的影响。
Sci Rep. 2020 Sep 14;10(1):14991. doi: 10.1038/s41598-020-71748-7.
6
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.COVID-19 疾病患者和未接触者体内针对 SARS-CoV-2 冠状病毒的 T 细胞反应的靶标。
Cell. 2020 Jun 25;181(7):1489-1501.e15. doi: 10.1016/j.cell.2020.05.015. Epub 2020 May 20.
7
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与神经内分泌应激轴。
Mol Psychiatry. 2020 Aug;25(8):1611-1617. doi: 10.1038/s41380-020-0758-9. Epub 2020 May 7.
8
Site-specific glycan analysis of the SARS-CoV-2 spike.新冠病毒刺突蛋白的糖基化位点特异性分析。
Science. 2020 Jul 17;369(6501):330-333. doi: 10.1126/science.abb9983. Epub 2020 May 4.
9
Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production.IgG B细胞受体的核心岩藻糖基化对于抗原识别和抗体产生是必需的。
J Immunol. 2015 Mar 15;194(6):2596-606. doi: 10.4049/jimmunol.1402678. Epub 2015 Feb 18.
10
Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease.血管紧张素转换酶2（ACE2）是健康与疾病状态下肾素血管紧张素系统的关键调节因子。
Int J Pept. 2012;2012:256294. doi: 10.1155/2012/256294. Epub 2012 Mar 20.