Postgraduate Program in Biophotonics Applied to the Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.
Postgraduate Program in Rehabilitation Sciences, UNINOVE, São Paulo, SP, Brazil.
J Biophotonics. 2022 Aug;15(8):e202200059. doi: 10.1002/jbio.202200059. Epub 2022 May 19.
This systematic review investigated the repercussions of photobiomodulation using low-level laser therapy (LLLT) for the treatment of spinal cord injury (SCI) in experimental models. Studies were identified from relevant databases published between January 2009 and December 2021. Nineteen original articles were selected and 68.4% used light at an infrared wavelength. There was a considerable variation of the power used (from 25 to 200 mW), total application time (8-3000 s) and total energy (0.3-450 J). In 79% of the studies, irradiation was initiated immediately after or within 2 h of the SCI, and treatment time ranged continuously from 5 to 21 days. In conclusion, LLLT can be an auxiliary therapy in the treatment of SCI, playing a neuroprotective role, enabling functional recovery, increasing the concentration of nerve connections around the injury site and reducing pro-inflammatory cytokines. However, there is a need for standardization in the dosimetric parameters.
本系统评价研究了低水平激光疗法（LLLT）用于治疗实验性脊髓损伤（SCI）的光生物调节作用的影响。研究从 2009 年 1 月至 2021 年 12 月发表的相关数据库中确定。选择了 19 篇原始文章，其中 68.4% 使用了红外波长的光。所用功率（25 至 200 mW）、总应用时间（8-3000 s）和总能量（0.3-450 J）差异很大。在 79%的研究中，照射是在 SCI 后立即或 2 小时内开始的，治疗时间连续从 5 天到 21 天不等。总之，LLLT 可以作为 SCI 治疗的辅助疗法，发挥神经保护作用，促进功能恢复，增加损伤部位周围神经连接的浓度，并减少促炎细胞因子。然而，剂量学参数需要标准化。
