免疫治疗联合化疗治疗的非小细胞肺癌患者因中草药引起的肝炎 1 例。
A case of hepatitis induced by herbal medicine in non-small cell lung cancer patient treated by a combination of immunotherapy and chemotherapy.
机构信息
Pharmacy Sterilization Department, 36604Strasbourg University Hospital, Strasbourg, France.
Pulmonology Department, 36604Strasbourg University Hospital, Strasbourg, France.
出版信息
J Oncol Pharm Pract. 2022 Dec;28(8):1926-1929. doi: 10.1177/10781552221090481. Epub 2022 Apr 28.
INTRODUCTION
Consumption of complementary and alternative medicine (CAM) is widely described in cancer patient. However, their composition is not clearly defined and the proofs of safety or effectiveness are quite low. We reported here the case of a CAM-induced hepatitis.
CASE SUMMARY
A 33-years-old men with Non-Small Cell Lung Cancer and treated by combination of immunotherapy and chemotherapy developed hepatitis during 5 months. Viral and iatrogenic etiologies were excluded.
MANAGEMENT AND OUTCOME
Medication reconciliation found concomitant utilisation of CAM. Some of the plants which composed CAM were found to be possible hepatotoxic. After discontinuation of this CAM, liver fonctions normalized. Close monitoring of liver function showed no other hepatitis.
DISCUSSION
CAM induced hepatotoxicity was suspected. Medication reconciliation included CAM is needed in cancer patient to detect drug interactions and CAM side effects to improve cancer patient management.
简介
补充和替代医学（CAM）的使用在癌症患者中被广泛描述。然而，其成分并不明确，安全性和有效性的证据也相当低。我们在此报告了一例 CAM 引起的肝炎。
病例总结
一名 33 岁男性患有非小细胞肺癌，接受免疫治疗和化疗联合治疗，在 5 个月期间发生肝炎。排除了病毒性和医源性病因。
治疗和结果
药物重审发现同时使用了 CAM。一些构成 CAM 的植物被发现可能具有肝毒性。停用 CAM 后，肝功能恢复正常。密切监测肝功能未发现其他肝炎。
讨论
怀疑 CAM 引起的肝毒性。在癌症患者中需要进行药物重审以检测药物相互作用和 CAM 的副作用，以改善癌症患者的管理。
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