Department of Cardiology. Giresun University Medical School.
Department of Cardiology. Giresun University.
Nutr Hosp. 2022 Jun 24;39(3):588-593. doi: 10.20960/nh.03995.
Background: it has been shown that vitamin B12 deficiency, which can cause hematological and neuropsychiatric disorders, may also be associated with cardiac autonomic dysfunction, heart rate variability, endothelial dysfunction, and a decrease in myocardial deformation. Aims: the aim of our study is to evaluate the relationship between vitamin B12 levels and electrocardiographic repolarization disorders, which are indicators of arrhythmogenic predisposition in healthy individuals. Methods: our study population consisted of 214 healthy adults. Considering the distribution of vitamin B12 levels and accepting 25 % and 75 % percentiles as the cut-off values, the participants were divided into 3 groups. Laboratory, echocardiography and electrocardiography (ECG) measurements were compared between three groups. ECG measurements were performed manually and Tpeak-Tend (Tp-e), Tp-e corrected (Tp-ec), QT and QT corrected (QTc) intervals were calculated. Results: the patients in Group 1 (vitamin B12 < 253 pg/ml) were found to have significantly higher QT and QTc dispersions, Tp-e interval, Tp-e/QT and Tp-e/QTc ratios when compared to those in Group 2 (253 pg/ml < vitamin B12 > 436 pg/ml) and Group 3 (vitamin B12 > 436 pg/ml). On the other hand, a negative significant correlation was detected between vitamin B12 levels and Tp-e, Tp-e/QT, Tp-e/QTc ratios, QT and QTc dispersions. Conclusion: a low level of vitamin B12 in healthy individuals can be a significant indicator of arrhythmogenic susceptibility. A close follow-up of these subjects in terms of arrhythmogenic predisposition can be useful.
维生素 B12 缺乏可导致血液系统和神经精神障碍，还可能与心脏自主神经功能障碍、心率变异性、内皮功能障碍和心肌变形减少有关。目的：本研究旨在评估维生素 B12 水平与心电图复极异常的关系，后者是健康个体心律失常易感性的指标。方法：我们的研究人群包括 214 名健康成年人。根据维生素 B12 水平的分布，接受 25%和 75%百分位数作为截止值，将参与者分为 3 组。比较三组的实验室、超声心动图和心电图（ECG）测量值。ECG 测量值是手动进行的，计算 Tpeak-Tend（Tp-e）、Tp-e 校正（Tp-ec）、QT 和 QT 校正（QTc）间期。结果：与 Group 2（253 pg/ml < 维生素 B12 > 436 pg/ml）和 Group 3（维生素 B12 > 436 pg/ml）相比，Group 1（维生素 B12 < 253 pg/ml）患者的 QT 和 QTc 离散度、Tp-e 间期、Tp-e/QT 和 Tp-e/QTc 比值明显更高。另一方面，检测到维生素 B12 水平与 Tp-e、Tp-e/QT、Tp-e/QTc 比值、QT 和 QTc 离散度之间存在显著负相关。结论：健康个体中维生素 B12 水平低可能是心律失常易感性的重要指标。对这些有发生心律失常倾向的患者进行密切随访可能是有用的。
