Phase 2 Vitamin C Sepsis Trials: Another Brick in the (Evidence) Wall?
作者信息
Agarwal Ankita, Oczkowski Simon, Sevransky Jonathan
机构信息
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Emory Center for Critical Care, Emory University, Atlanta, GA.
出版信息
Crit Care Med. 2022 May 1;50(5):897-899. doi: 10.1097/CCM.0000000000005432. Epub 2022 Apr 11.
Abstract
摘要
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本文引用的文献
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Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy.评估维生素 C 在感染性休克中的作用：维生素 C 单药治疗的随机对照试验。
Crit Care Med. 2022 May 1;50(5):e458-e467. doi: 10.1097/CCM.0000000000005427. Epub 2022 Jan 5.
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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.执行摘要：拯救脓毒症运动：2021年脓毒症和脓毒性休克管理国际指南。
Crit Care Med. 2021 Nov 1;49(11):1974-1982. doi: 10.1097/CCM.0000000000005357.
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.拯救脓毒症运动：2021年脓毒症和脓毒性休克国际管理指南
Crit Care Med. 2021 Nov 1;49(11):e1063-e1143. doi: 10.1097/CCM.0000000000005337.
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21st Century Evidence: Randomized Controlled Trials Versus Systematic Reviews and Meta-Analyses.21世纪的证据：随机对照试验与系统评价和荟萃分析
Crit Care Med. 2021 Dec 1;49(12):2001-2002. doi: 10.1097/CCM.0000000000005343.
5
Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.硫胺素、抗坏血酸和氢化可的松作为脓毒症代谢复苏鸡尾酒：随机对照试验的荟萃分析及序贯试验分析。
Crit Care Med. 2021 Dec 1;49(12):2112-2120. doi: 10.1097/CCM.0000000000005262.
6
Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.IV 高剂量维生素 C 对脓毒症患者死亡率的影响：随机对照试验的系统评价和荟萃分析。
Crit Care Med. 2021 Dec 1;49(12):2121-2130. doi: 10.1097/CCM.0000000000005263.
7
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.维生素 C、硫胺素和氢化可的松对败血症患者呼吸机和血管加压素无使用天数的影响：VICTAS 随机临床试验。
JAMA. 2021 Feb 23;325(8):742-750. doi: 10.1001/jama.2020.24505.
8
Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study.维生素 C 和硫胺素联合治疗感染性休克的多中心、双盲随机对照研究。
Intensive Care Med. 2020 Nov;46(11):2015-2025. doi: 10.1007/s00134-020-06191-3. Epub 2020 Aug 11.
9
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis: The ORANGES Trial.抗坏血酸、硫胺素和糖皮质激素用于脓毒症早期代谢复苏的结局：ORANGES 试验。
Chest. 2020 Jul;158(1):164-173. doi: 10.1016/j.chest.2020.02.049. Epub 2020 Mar 17.
10
Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.维生素 C、氢化可的松和硫胺素与单独使用氢化可的松对感染性休克患者存活时间和脱离血管加压支持的影响：VITAMINS 随机临床试验。
JAMA. 2020 Feb 4;323(5):423-431. doi: 10.1001/jama.2019.22176.
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