Postgraduate Program of Biomedical Sciences, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia.
Indramayu State Polytechnic.
Asian Pac J Cancer Prev. 2022 Apr 1;23(4):1169-1175. doi: 10.31557/APJCP.2022.23.4.1169.
This study aimed to investigate the association between intra-tumoral and stromal VDR expressions with molecular subtypes and clinicopathological factors.
A total of 75 formalin-fixed paraffin embedded tissue samples were stained using immunohistochemical methods. The VDR expressions were measured by counting brown-stained nuclei in intra-tumoral and stromal areas. The association of VDR expression with molecular subtypes and clinopathological factors was examined. Statistical analysis was performed by chi square tests.
High intra-tumoral VDR expression was found in carcinomas with luminal molecular subtypes (p=0.039) and low histological degrees (p=0.035). High VDR expression in the stroma was found in breast carcinomas with large tumor sizes.
High intra-tumoral VDR expression is found in breast carcinomas with luminal subtypes and low histological grade (I/II). Both factors are known to have a good prognosis. These findings further strengthen the function of VDR as anti-tumorigenesis.
本研究旨在探讨肿瘤内和基质中 VDR 表达与分子亚型和临床病理因素的关系。
采用免疫组织化学方法对 75 例福尔马林固定石蜡包埋组织样本进行染色。通过计数肿瘤内和基质区域中棕色染色核来测量 VDR 表达。通过卡方检验检查 VDR 表达与分子亚型和临床病理因素的关系。
高肿瘤内 VDR 表达见于腔型分子亚型的癌（p=0.039）和低组织学分级的癌（p=0.035）。基质中 VDR 高表达见于大肿瘤大小的乳腺癌。
高肿瘤内 VDR 表达见于腔型分子亚型和低组织学分级（I/II）的乳腺癌。这两个因素均具有良好的预后。这些发现进一步加强了 VDR 的抗肿瘤作用。
