乳腺癌组织内肿瘤细胞和基质中维生素 D 受体（VDR）表达与分子亚型及临床病理因素的相关性研究。
The Association of Intra-Tumoral and Stromal Vitamin D Receptor (VDR) Expressions with Molecular Subtypes and Clinicopathological Factors in Breast Carcinoma.
机构信息
Postgraduate Program of Biomedical Sciences, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia.
Indramayu State Polytechnic.
出版信息
Asian Pac J Cancer Prev. 2022 Apr 1;23(4):1169-1175. doi: 10.31557/APJCP.2022.23.4.1169.
OBJECTIVE
This study aimed to investigate the association between intra-tumoral and stromal VDR expressions with molecular subtypes and clinicopathological factors.
METHODS
A total of 75 formalin-fixed paraffin embedded tissue samples were stained using immunohistochemical methods. The VDR expressions were measured by counting brown-stained nuclei in intra-tumoral and stromal areas. The association of VDR expression with molecular subtypes and clinopathological factors was examined. Statistical analysis was performed by chi square tests.
RESULTS
High intra-tumoral VDR expression was found in carcinomas with luminal molecular subtypes (p=0.039) and low histological degrees (p=0.035). High VDR expression in the stroma was found in breast carcinomas with large tumor sizes.
CONCLUSIONS
High intra-tumoral VDR expression is found in breast carcinomas with luminal subtypes and low histological grade (I/II). Both factors are known to have a good prognosis. These findings further strengthen the function of VDR as anti-tumorigenesis.
目的
本研究旨在探讨肿瘤内和基质中 VDR 表达与分子亚型和临床病理因素的关系。
方法
采用免疫组织化学方法对 75 例福尔马林固定石蜡包埋组织样本进行染色。通过计数肿瘤内和基质区域中棕色染色核来测量 VDR 表达。通过卡方检验检查 VDR 表达与分子亚型和临床病理因素的关系。
结果
高肿瘤内 VDR 表达见于腔型分子亚型的癌（p=0.039）和低组织学分级的癌（p=0.035）。基质中 VDR 高表达见于大肿瘤大小的乳腺癌。
结论
高肿瘤内 VDR 表达见于腔型分子亚型和低组织学分级（I/II）的乳腺癌。这两个因素均具有良好的预后。这些发现进一步加强了 VDR 的抗肿瘤作用。
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