钙摄入量与胶质瘤风险的 Meta 分析。
A Meta-Analysis of Calcium Intake and Risk of Glioma.
机构信息
Department of Neurosurgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
出版信息
Nutr Cancer. 2022;74(9):3194-3201. doi: 10.1080/01635581.2022.2067336. Epub 2022 Apr 29.
BACKGROUND
A meta-analysis was conducted to investigate the correlation between calcium intake and the risk of brain tumors (especially glioma).
METHODS
The PubMed, Web of Science, and Embase databases were searched for relevant papers on the association between calcium intake and glioma as of August 22, 2021. The odds ratio (OR) with a 95% confidence interval (CI) was calculated using a random-effects model. Egger's test was conducted to assess publication bias.
RESULTS
The meta-analysis includes four studies. The meta-analysis showed that calcium intake and the risk of brain tumors have a significant negative relationship (OR = 0.28; 95% CI: 0.11 to 0.72; = 0.008). Dose-response analysis showed that for every 100 mg/day increase in calcium intake, the risk of glioma decreased by 7% (OR = 0.93; 95% CI: 0.88 to 0.98). In addition, compared with humans without calcium intake, when calcium intake is 455 mg/day, 800 mg/day and 1000 mg/day, the risk of glioma is 0.65 (95% CI 0.43, 0.97), 0.55 (95% CI 0.37, 0.82) and 0.37 (95% CI 0.15, 0.86).
CONCLUSION
There is a significant negative association between calcium intake and brain tumors (especially gliomas), but more high-quality studies are needed to verify these results.
背景
进行了一项荟萃分析，以研究钙摄入量与脑肿瘤（尤其是胶质瘤）风险之间的相关性。
方法
检索了截至 2021 年 8 月 22 日PubMed、Web of Science 和 Embase 数据库中关于钙摄入量与胶质瘤之间关联的相关文献。使用随机效应模型计算比值比（OR）及其 95%置信区间（CI）。采用 Egger 检验评估发表偏倚。
结果
荟萃分析纳入了四项研究。荟萃分析表明，钙摄入量与脑肿瘤风险呈显著负相关（OR=0.28；95%CI：0.11 至 0.72；P=0.008）。剂量-反应分析表明，钙摄入量每增加 100mg/天，胶质瘤风险降低 7%（OR=0.93；95%CI：0.88 至 0.98）。此外，与无钙摄入的人群相比，当钙摄入量分别为 455mg/天、800mg/天和 1000mg/天时，胶质瘤的风险分别为 0.65（95%CI 0.43，0.97）、0.55（95%CI 0.37，0.82）和 0.37（95%CI 0.15，0.86）。
结论
钙摄入量与脑肿瘤（尤其是胶质瘤）之间存在显著负相关，但需要更多高质量的研究来验证这些结果。
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