吸烟会增加患神经胶质瘤的风险吗？一项基于病例对照研究的荟萃分析。
Does smoking increase the risk of developing glioma? A meta-analysis based on case-control studies.
作者信息
Guo Xiaqing, Wang Yabo
机构信息
Department of Neurology, Henan University Huaihe Hospital, Kaifeng, Henan, P.R. China.
出版信息
J Cancer Res Ther. 2016 Dec;12(Supplement):C301-C303. doi: 10.4103/0973-1482.200758.
OBJECTIVE
The purpose of this study was to assess the relationship between smoking and glioma risk by meta-analysis.
MATERIALS AND METHODS
We have searched the databases of MEDLINE, EMBASE, Ovid, and CNKI to find the suitable studies related to association between smoking and glioma risk. The pooled odds ratio (OR) and 95% confidence interval (CI) of smokers in glioma patients compared to normal controls were aggregated by statistic software Stata11.0. The publication bias was evaluated by Begg's funnel plot.
RESULTS
Finally, seven case-control studies were included in this meta-analysis. The pooled results showed that smoking did not increase the risk of glioma (OR = 0.96, 95% CI = 0.86-1.07, P > 0.05).
CONCLUSION
No close association between smoking and glioma risk was found in this meta-analysis, which indicate that smoking may not contribute to the incidence of glioma.
目的
本研究旨在通过荟萃分析评估吸烟与胶质瘤风险之间的关系。
材料与方法
我们检索了MEDLINE、EMBASE、Ovid和中国知网数据库，以查找与吸烟和胶质瘤风险关联相关的合适研究。使用统计软件Stata11.0汇总胶质瘤患者中吸烟者与正常对照相比的合并优势比（OR）和95%置信区间（CI）。通过Begg漏斗图评估发表偏倚。
结果
最终，本荟萃分析纳入了七项病例对照研究。汇总结果显示，吸烟并未增加患胶质瘤的风险（OR = 0.96，95%CI = 0.86 - 1.07，P > 0.05）。
结论
本荟萃分析未发现吸烟与胶质瘤风险之间存在密切关联，这表明吸烟可能与胶质瘤的发病无关。
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