School of Life Sciences, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
CUHK Shenzhen Research Institute, Shenzhen, China.
FEBS Lett. 2022 Sep;596(17):2314-2323. doi: 10.1002/1873-3468.14362. Epub 2022 May 11.
In eukaryotes, the endomembrane system allows for spatiotemporal compartmentation of complicated cellular processes. The plant endomembrane system consists of the endoplasmic reticulum, the Golgi apparatus, the trans-Golgi network, the multivesicular body and the vacuole. Anterograde traffic from the endoplasmic reticulum to the Golgi apparatus is mediated by coat protein complex II (COPII) vesicles. Autophagy, an evolutionarily conserved catabolic process that turns over cellular materials upon nutrient deprivation or in adverse environments, exploits double-membrane autophagosomes to recycle unwanted constituents in the lysosome/vacuole. Accumulating evidence reveals novel functions of plant COPII vesicles in autophagy and their regulation by abiotic stresses. Here, we summarize current knowledge about plant COPII vesicles in endomembrane trafficking and then highlight recent findings showing their distinct roles in modulating the autophagic flux and stress responses.
在真核生物中，内膜系统允许复杂的细胞过程在时空上分隔开。植物内膜系统包括内质网、高尔基体、反式高尔基体网络、多泡体和液泡。内质网到高尔基体的正向运输是由衣壳蛋白复合物 II（COPII）囊泡介导的。自噬是一种保守的分解代谢过程，在营养缺乏或不利环境下会分解细胞物质，利用双层膜自噬体在溶酶体/液泡中回收不需要的成分。越来越多的证据表明植物 COPII 囊泡在自噬中的新功能及其对非生物胁迫的调节。在这里，我们总结了目前关于植物 COPII 囊泡在内膜运输中的知识，然后强调了最近的发现，这些发现显示了它们在调节自噬通量和应激反应中的独特作用。
