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造血细胞足以引发 POLB-Y265C 突变导致的狼疮。

The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.

机构信息

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, United States of America.

Department of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, United States of America.

出版信息

PLoS One. 2022 Apr 29;17(4):e0267913. doi: 10.1371/journal.pone.0267913. eCollection 2022.

DOI:10.1371/journal.pone.0267913
PMID:35486639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9053796/
Abstract

Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLBY265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether the hematopoietic compartment is sufficient for lupus development, we transplanted bone marrow cells from POLBY265C/C and POLB+/+ into wild-type congenic mice. Only mice transplanted with the POLBY265C/C bone marrow develop high levels of antinuclear antibodies and renal disease. In conclusion, we show that the hematopoietic compartment harvested from the POLBY265C/C mice is sufficient for development of autoimmune disease.

摘要

系统性红斑狼疮是一种以自身抗体、肾脏和皮肤疾病以及免疫复合物形成为特征的慢性疾病。新出现的证据表明，异常的 DNA 修复是狼疮发展的潜在机制。我们之前曾表明，POLBY265C/C 突变导致异常免疫受体的产生，导致小鼠发生狼疮样疾病。为了确定造血细胞是否足以引起狼疮的发生，我们将 POLBY265C/C 和 POLB+/+的骨髓细胞移植到野生型同基因小鼠中。只有接受 POLBY265C/C 骨髓移植的小鼠才会产生高水平的抗核抗体和肾脏疾病。总之，我们表明，从 POLBY265C/C 小鼠中采集的造血细胞足以发展自身免疫性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/b019b6f47842/pone.0267913.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/b9e75e6c0964/pone.0267913.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/c78a58025d43/pone.0267913.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/b019b6f47842/pone.0267913.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/b9e75e6c0964/pone.0267913.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/c78a58025d43/pone.0267913.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a0/9053796/b019b6f47842/pone.0267913.g003.jpg

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