Department of Ophthalmology, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
Department of Uveal Diseases, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
Ocul Immunol Inflamm. 2023 Aug;31(6):1206-1209. doi: 10.1080/09273948.2022.2061523. Epub 2022 Apr 29.
To present a case of panuveitis with granulomatous intraocular inflammation and vasculitis related to coronavirus disease 2019 (COVID-19).
A 46-year-old female patient had blurred vision in both eyes during 8 days after COVID-19 symptoms. Anterior segment examination revealed anterior chamber cells in the both eyes, mutton fat keratic precipitates and posterior synechiae in the left eye. Small peripheral iris nodules and mild vitritis were accompanying in both eyes. Fundus examination revealed multiple superficial retinal infiltrate lesions in the peripheral retina with retinal periphlebitis in both eyes. Spectral domain optical coherence tomography showed hyperreflective superficial retinal infiltrates. Fluorescein angiography (FA) and indocyanine green angiography demonstrated hypofluorescent foci due to blockade of retinal infiltrates. Peripheral vascular leakage was detected on FA in both eyes.
This case showed that COVID-19 infection can cause granulomatous panuveitis. Autoimmune mechanisms related to COVID-19 may lead to ocular inflammation.
报告一例与 2019 年冠状病毒病（COVID-19）相关的全葡萄膜炎伴肉芽肿性眼内炎症和血管炎。
一名 46 岁女性患者在 COVID-19 症状出现后 8 天出现双眼视力模糊。眼前节检查显示双眼前房细胞、左眼羊脂状角膜后沉着物和后粘连。双眼伴有小周边虹膜结节和轻度睫状体炎。眼底检查显示双眼周边视网膜多发性浅层视网膜浸润伴视网膜血管炎。频域光相干断层扫描显示浅层视网膜高反射性浸润。荧光素血管造影（FA）和吲哚青绿血管造影显示由于视网膜浸润阻塞导致的低荧光病灶。双眼 FA 显示外周血管渗漏。
本病例表明 COVID-19 感染可引起肉芽肿性全葡萄膜炎。与 COVID-19 相关的自身免疫机制可能导致眼部炎症。
