Department of Dermatology, University of Kocaeli, Kocaeli, Turkey.
J Cosmet Dermatol. 2022 Oct;21(10):5141-5147. doi: 10.1111/jocd.15005. Epub 2022 May 10.
Human demodex mites are parasites that live in the pilosebaceous unit and can result in the disease demodicosis. While demodicosis may occur as a primary skin disease; immunosuppression, and topical or systemic immunosuppressive treatments can cause secondary demodicosis. It is known that thyroid hormones may cause skin changes, such as xerosis, and thereby may also modulate immune responses in the skin.
The aim of this study is to investigate whether or not that the changes occurring in the skin of patients with Hashimoto's Thyroiditis (HT) predispose to demodex infestation.
Seventy-eight patients being followed for a diagnosis of HT at Kocaeli University Endocrinology Outpatient Clinic, between January 2019 and March 2020, constituted the patient group. The control group consisted of 41 patients who did not have any chronic systemic or dermatological disease and were shown to have no thyroid disease by laboratory tests. Demodex intensity in the malar regions of the patient and control groups was determined using the standardized skin surface biopsy (SSSB) method and compared with each other.
HT patients were significantly more likely to have increased demodex density and suggestive SSSB results than the controls (p < 0.001, p = 0.012, respectively). A significant correlation was found between demodex intensity and the findings of xerosis (p = 0.010, p = 0.011) and spiny follicular papules (p = 0.008, p = 0.008) in the patient or control groups, respectively. However, a significant correlation was identified between the demodex density and the symptoms of burning-stinging (p = 0.028), and feelings of dryness (p = 0.018) roughness (p = 0.028) only in the control group.
Xerotic skin and/or impaired immune responses as a result of autoimmune changes in patients with HT may lead to secondary demodicosis.
人体蠕形螨是一种寄生在毛囊皮脂腺单位的寄生虫，可导致蠕形螨病。虽然蠕形螨病可能是一种原发性皮肤病；但免疫抑制和局部或全身免疫抑制治疗可导致继发性蠕形螨病。已知甲状腺激素可引起皮肤变化，如干燥，从而也可能调节皮肤的免疫反应。
本研究旨在探讨桥本甲状腺炎（HT）患者皮肤变化是否易患蠕形螨感染。
2019 年 1 月至 2020 年 3 月，在科贾埃利大学内分泌门诊接受 HT 诊断的 78 例患者为患者组。对照组由 41 例无慢性系统性或皮肤病且实验室检查无甲状腺疾病的患者组成。使用标准化皮肤表面活检（SSSB）法比较患者和对照组的颊部蠕形螨强度，并进行比较。
HT 患者的蠕形螨密度和提示性 SSSB 结果明显高于对照组（p<0.001，p=0.012）。分别在患者和对照组中，均发现蠕形螨强度与干燥（p=0.010，p=0.011）和棘状滤泡丘疹（p=0.008，p=0.008）之间存在显著相关性。然而，仅在对照组中，蠕形螨密度与灼热刺痛感（p=0.028）和干燥感（p=0.018）之间存在显著相关性。
HT 患者由于自身免疫变化引起的皮肤干燥和/或免疫反应受损，可能导致继发性蠕形螨病。
