Burke J M, McDonald H R, Neuwirth J, Lewandowski M
Arch Ophthalmol. 1987 Mar;105(3):404-8. doi: 10.1001/archopht.1987.01060030124041.
Titanium retinal tacks were implanted through the formed vitreous into the posterior retinas of rabbits and evaluated by electroretinographic testing and by light microscopy at intervals after implantation. Tritiated thymidine autoradiography was used to evaluate the proliferation of ocular tissues in response to tack insertion. Within one month after implantation, the retinal tacks were surrounded by scar tissue produced by the proliferation of retinal glial cells and choroidal and scleral connective tissue cells. The tissue response was focal and there was no excessive fibrous tissue or vascular proliferation or any indication of iris neovascularization for six months. The observations of firm retinal adherence and low tissue reactivity suggest that titanium tacks can be used to secure the retina during retinal attachment surgery and can remain permanently in the eye.
将钛制视网膜钉通过形成的玻璃体植入兔眼后视网膜，并在植入后的不同时间间隔通过视网膜电图测试和光学显微镜进行评估。使用氚标记的胸腺嘧啶核苷放射自显影术来评估眼组织对钉插入的增殖反应。植入后一个月内，视网膜钉被视网膜神经胶质细胞、脉络膜和巩膜结缔组织细胞增殖产生的瘢痕组织所包围。组织反应是局灶性的，六个月内没有过度的纤维组织或血管增殖，也没有虹膜新生血管的迹象。视网膜牢固附着和低组织反应性的观察结果表明，钛钉可用于视网膜附着手术中固定视网膜，并可永久留在眼内。
