在窒息性心脏骤停大鼠模型中，电针通过α7烟碱型乙酰胆碱受体介导的神经炎症抑制作用减轻脑损伤。
Electroacupuncture attenuates brain injury through α7 nicotinic acetylcholine receptor-mediated suppression of neuroinflammation in a rat model of asphyxial cardiac arrest.
作者信息
Liu Yongfei, Zhang Li, Han Ruili, Bai Weiping, Li Juan, Gao Changjun
机构信息
Department of Anesthesiology, Tangdu Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710038, China.
Department of Anesthesiology, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi 710016, China.
出版信息
J Neuroimmunol. 2022 Jun 15;367:577873. doi: 10.1016/j.jneuroim.2022.577873. Epub 2022 Apr 20.
We determined whether electroacupuncture (EA) ameliorated brain injury following asphyxial cardiac arrest (CA) and evaluated the role of the α7 nicotinic acetylcholine receptor (α7nAChR)-mediated anti-inflammatory pathway. In CA-induced rats, EA reduced brain injury and promoted behavioral recovery. Morris water maze escape latency time reduced after Baihui (GV20) and Shuigou (DU26) stimulation. EA reduced α7nAChR downregulation after cardiopulmonary resuscitation (CPR), reducing tumor necrosis factor alpha, interleukin-1, and interleukin-6 expression and ionized calcium binding adapter molecule 1 production. The α7nAChR antagonist methyllycaconitine reversed EA effect. EA stimulation of acupuncture points alleviated brain damage after CPR and reduced the inflammatory response via α7nAChR activation.
我们确定了电针（EA）是否能改善窒息性心脏骤停（CA）后的脑损伤，并评估了α7烟碱型乙酰胆碱受体（α7nAChR）介导的抗炎途径的作用。在CA诱导的大鼠中，EA减轻了脑损伤并促进了行为恢复。刺激百会（GV20）和水沟（DU26）后，莫里斯水迷宫逃避潜伏期缩短。EA减少了心肺复苏（CPR）后α7nAChR的下调，降低了肿瘤坏死因子α、白细胞介素-1和白细胞介素-6的表达以及离子钙结合衔接分子1的产生。α7nAChR拮抗剂甲基lycaconitine逆转了EA的作用。针刺穴位的EA刺激减轻了CPR后的脑损伤，并通过激活α7nAChR减少了炎症反应。
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