The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase: a molecular modelling study.
作者信息
Gouaux J E, Krause K L, Lipscomb W N
出版信息
Biochem Biophys Res Commun. 1987 Feb 13;142(3):893-7. doi: 10.1016/0006-291x(87)91497-5.
PMID:3548720
Abstract
Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino group of L-aspartate and a terminal phosphate oxygen of carbamoylphosphate.
摘要
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