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本文引用的文献

1
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.白细胞介素 1 和白细胞介素 1 受体拮抗剂是 RNA 疫苗引发炎症反应的关键调节因子。
Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24.
2
The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory.临床前疫苗研究中使用的mRNA-LNP平台的脂质纳米颗粒成分具有高度炎症性。
iScience. 2021 Dec 17;24(12):103479. doi: 10.1016/j.isci.2021.103479. Epub 2021 Nov 20.
3
From lipids to lipid nanoparticles to mRNA vaccines.从脂质到脂质纳米颗粒再到信使核糖核酸疫苗。
Nat Rev Mater. 2021;6(12):1075-1076. doi: 10.1038/s41578-021-00379-9. Epub 2021 Sep 21.
4
The tangled history of mRNA vaccines.信使核糖核酸疫苗的复杂历史。
Nature. 2021 Sep;597(7876):318-324. doi: 10.1038/d41586-021-02483-w.
5
Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines.基于脂质纳米颗粒的新冠疫苗的过敏反应和过敏症
Mol Ther. 2021 Mar 3;29(3):898-900. doi: 10.1016/j.ymthe.2021.01.030. Epub 2021 Feb 5.
6
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.核苷修饰的 mRNA 疫苗可诱导强烈的滤泡辅助性 T 细胞和生发中心 B 细胞反应。
J Exp Med. 2018 Jun 4;215(6):1571-1588. doi: 10.1084/jem.20171450. Epub 2018 May 8.
7
The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation.正电脂质纳米颗粒的全身毒性及 Toll 样受体 4 在免疫激活中的作用。
Biomaterials. 2010 Sep;31(26):6867-75. doi: 10.1016/j.biomaterials.2010.05.027. Epub 2010 Jun 11.

Pro-inflammatory concerns with lipid nanoparticles.

作者信息

Moghimi Seyed Moein, Simberg Dmitri

机构信息

Associate Editor - Molecular Therapy; School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; Translational and Clinical Research Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Translational Bio-Nanosciences Laboratory, Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

出版信息

Mol Ther. 2022 Jun 1;30(6):2109-2110. doi: 10.1016/j.ymthe.2022.04.011. Epub 2022 Apr 28.

DOI:10.1016/j.ymthe.2022.04.011
PMID:35487214
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9047613/
Abstract
摘要