Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Acta Biomater. 2022 Jul 1;146:197-210. doi: 10.1016/j.actbio.2022.04.040. Epub 2022 Apr 27.
Exposure to a nuclear accident or a radiological attack may cause serious death events due to ionizing radiation-induced injury and acute radiation syndrome (ARS). Recombinant human granulocyte colony-stimulating factor (G-CSF) is now used for the treatment of ARS. However, the current injection formulation might not ensure treatment as early as possible after a nuclear accident, resulting in a decrease in therapeutic efficiency. In the present study, we have developed a G-CSF wearable system (GWS) consisting of a commercial microchip, a temperature sensor, a gamma-ray detection sensor, a flexible heater, and a G-CSF temperature-sensitive microneedle (GTSMN) patch. G-CSF-containing hyaluronic acid solutions were cast into the mold to obtain G-CSF microneedles (GMNs), which were coated with a temperature-sensitive layer of dodecanoic acid-cetylamine salt to obtain GTSMNs. The flexible heater was prepared by jet printing Ag nanoparticle inks. The GWS and its components are explored and optimized in the aspects of electronics, mechanics, heat transfer and drug diffusion. The γ radiation signal is sensitively monitored by the GWS. The wearable G-CSF system immediately releases G-CSF into the body in response to signal feedback and provides maximal protection against ionizing radiation-induced injury. Therefore, the GWS is a promising wearable system against emergent ionizing radiation injury. STATEMENT OF SIGNIFICANCE: Ionizing radiation-induced injury is always the very important public health problem all the global people care. Some medicines have been applied to protect the body from the injury. Unfortunately, sometimes the injuries accidently happen and the medicines cannot be administered in time, leading to serious acute radiation syndrome. Here, we design a wearable system loading G-CSF that has been approved by FDA to protect the body from ionizing radiation-induced injury. This system consists of a commercial microchip, a temperature sensor, a Gamma-ray detection sensor, a flexible heater, and a G-CSF temperature-sensitive microneedle patch. It can monitor γ radiation and immediately release G-CSF into the body to protect the body to the maximal extent. Therefore, the system is a promising wearable medical device against emergent ionizing radiation injury.
接触核事故或放射性袭击可能会导致严重的死亡事件，原因是电离辐射引起的损伤和急性辐射综合征（ARS）。重组人粒细胞集落刺激因子（G-CSF）现用于治疗 ARS。然而，目前的注射制剂可能无法确保在核事故后尽早进行治疗，从而降低了治疗效率。在本研究中，我们开发了一种由商业微芯片、温度传感器、伽马射线检测传感器、柔性加热器和 G-CSF 温度敏感型微针（GTSMN）贴片组成的 G-CSF 可穿戴系统（GWS）。将含 G-CSF 的透明质酸溶液浇铸到模具中以获得 G-CSF 微针（GMN），然后将其涂覆一层十二烷酸-鲸蜡胺盐的温度敏感层以获得 GTSMN。通过喷射打印 Ag 纳米粒子油墨制备柔性加热器。从电子、力学、传热和药物扩散等方面对 GWS 及其组件进行了探索和优化。GWS 可以灵敏地监测 γ 辐射信号。可穿戴 G-CSF 系统会根据信号反馈立即将 G-CSF 释放到体内，为身体提供最大的保护，防止电离辐射引起的损伤。因此，GWS 是一种有前途的可穿戴系统，可对抗突发的电离辐射损伤。
电离辐射引起的损伤一直是全球人民都非常关注的重要公共卫生问题。一些药物已被应用于保护身体免受伤害。不幸的是，有时伤害事故发生，药物无法及时给予，导致严重的急性辐射综合征。在这里，我们设计了一种可穿戴系统，该系统装载了已获得 FDA 批准的 G-CSF，以保护身体免受电离辐射引起的损伤。该系统由商业微芯片、温度传感器、伽马射线检测传感器、柔性加热器和 G-CSF 温度敏感型微针贴片组成。它可以监测 γ 辐射，并立即将 G-CSF 释放到体内，以最大程度地保护身体。因此，该系统是一种有前途的可穿戴医疗设备，可对抗突发的电离辐射损伤。
