He Lixue, Edi Shixing, Ma Jun, Kong Zilin, Dai Chunguang, Huang Linfang, Zeng Rui, Gou Kaijun
School of Pharmacy, Southwest Minzu University, Chengdu 610225, China.
Key Laboratory of Chinese Medicine Resources Conservation of National Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Chin Herb Med. 2024 Sep 13;17(2):220-234. doi: 10.1016/j.chmed.2024.09.005. eCollection 2025 Apr.
Nuclear radiation exposure events and tumor radiotherapy are highly susceptible to a range of psychological, physiological and other health problems, which can seriously affect patients' quality of life. It has been shown that 87.5 % of tumor patients are exposed to varying degrees of radiation injury during radiotherapy. The treatment of radiation injury (RI) in modern medicine is limited to drug therapy, cell therapy, etc. Among them, the most chemical drugs cause many adverse reactions including fatigue, nausea, vomiting, etc., and there are very few drugs dedicated to the treatment of RI. Traditional Chinese medicine (TCM) is a rich natural medicinal resource, which has a wide range of pharmacological activities, multiple targets of action and minimal toxic side effects. Many studies have demonstrated that TCM and its compound preparations have enormous potential in the treatment of radiation induced comprehensive diseases. However, TCM is limited in clinical application due to its slow onset of action, complex active ingredients, and low bioavailability. Therefore, the article reviews the application, molecular mechanisms, and new dosage forms of TCM in the prevention and treatment of RI. On this basis, we will focus on discussing the development advantages and application prospects of the combination of traditional Chinese and Western medicine to achieve highly efficient treatment of RI. This review aims to provide scientific and effective drug delivery strategies and basic theoretical support for the clinical effective treatment of RI with TCM, and further promote the innovative development of TCM.
核辐射暴露事件和肿瘤放射治疗极易引发一系列心理、生理及其他健康问题，这会严重影响患者的生活质量。研究表明，87.5%的肿瘤患者在放射治疗期间会受到不同程度的辐射损伤。现代医学对辐射损伤（RI）的治疗局限于药物治疗、细胞治疗等。其中，大多数化学药物会引发诸多不良反应，包括疲劳、恶心、呕吐等，而专门用于治疗RI的药物极少。中药是丰富的天然药物资源，具有广泛的药理活性、多个作用靶点且毒副作用极小。许多研究表明，中药及其复方制剂在治疗辐射诱发的综合性疾病方面具有巨大潜力。然而，中药因其起效缓慢、活性成分复杂且生物利用度低，在临床应用中受到限制。因此，本文综述了中药在RI防治中的应用、分子机制及新剂型。在此基础上，我们将重点探讨中西医结合的发展优势及应用前景，以实现对RI的高效治疗。本综述旨在为中药临床有效治疗RI提供科学有效的给药策略及基础理论支持，并进一步推动中药的创新发展。
