Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production, University of Bari "Aldo Moro", Bari, Italy.
Department of Small Animal Orthopaedics and Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Vet J. 2022 May-Jun;283-284:105832. doi: 10.1016/j.tvjl.2022.105832. Epub 2022 Apr 27.
The aim of this multi-centred, cohort, prospective, observational study was to evaluate the clinical application of the canine osteoarthritis staging tool (COAST), in dogs affected by osteoarthritis (OA). In all dogs, a COAST stage was obtained based on the Liverpool Osteoarthritis in Dogs (LOAD) score and a complete orthopaedic and radiographic examination. The severity of OA (COAST stage) was scored as 1 (preclinical), 2 (mild), 3 (moderate), and 4 (severe). These scores were compared with the overall subjective opinion of experienced orthopaedic surgeons who examined the dogs (Clinical Opinion). Data were analysed with descriptive statistic, multiple regression analysis, chi-square and Bland-Altman tests (P < 0.05). In total, 362 evaluations were performed in 202 dogs. Clinical Opinion had a greater proportion of stage 1 and 2 cases compared to COAST (P < 0.0001). The proportion of stage 4 cases was higher in COAST compared to Clinical Opinion (P < 0.0001). The proportions of Stage 3 cases were similar in the two evaluation systems. COAST had a strong correlation (r = 0.79; P < 0.01) with Clinical Opinion. Overall, the two evaluation systems exhibited strong agreement (mean bias 0.51). Stages 1 and 2 had weaker agreement (mean bias 1.04 and 0.75, respectively), than stage 3 and stage 4 (mean bias 0.46 and 0.0, respectively).
本多中心、队列、前瞻性、观察性研究的目的是评估犬骨关节炎分期工具（COAST）在患有骨关节炎（OA）的犬中的临床应用。在所有犬中，根据利物浦犬骨关节炎（LOAD）评分和完整的骨科和放射学检查获得 COAST 分期。OA 的严重程度（COAST 分期）评分为 1（临床前）、2（轻度）、3（中度）和 4（重度）。这些评分与检查犬的经验丰富的骨科外科医生的总体主观意见（临床意见）进行比较。使用描述性统计、多元回归分析、卡方和 Bland-Altman 检验（P<0.05）进行数据分析。总共对 202 只犬进行了 362 次评估。临床意见的 1 期和 2 期病例比例高于 COAST（P<0.0001）。COAST 中 4 期病例的比例高于临床意见（P<0.0001）。两种评估系统中 3 期病例的比例相似。COAST 与临床意见具有很强的相关性（r=0.79；P<0.01）。总体而言，两种评估系统具有很强的一致性（平均偏差 0.51）。1 期和 2 期的一致性较弱（平均偏差分别为 1.04 和 0.75），而 3 期和 4 期的一致性较强（平均偏差分别为 0.46 和 0.0）。
