Laboratory of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Laboratory of Internal Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
J Comp Pathol. 2022 May;193:20-24. doi: 10.1016/j.jcpa.2022.02.006. Epub 2022 Mar 31.
We investigated the pathological characteristics of renal dysplasia with hydronephrosis and congenital ureteral stricture in two calves. Macroscopically, the affected kidneys were enlarged and the renal calyces were dilated and associated with ureteral strictures. Histopathologically, multifocal regions of mesenchyme were observed in the renal medulla. This mesenchyme was weakly eosinophilic with haematoxylin and eosin, blue with Alcian blue and pale blue with Masson's trichrome, and was immunopositive for vimentin and smooth muscle actin, consistent with persistent mesenchyme. There was asynchronous differentiation of the renal cortex characterized by immature glomeruli, immature tubules and arteriolar proliferation. Similar persistent mesenchyme was observed in the ureteral walls with ureteral stricture, and the ureteral musculature or smooth muscle bundles had a disorganized arrangement. Congenital ureteral stricture appeared to have caused ureteral obstruction and hydronephrosis. The lesions may represent a new phenotype of renal dysplasia with concomitant congenital ureteral stricture in Holstein-Friesian calves.
我们研究了两例患有肾发育不良伴肾盂积水和先天性输尿管狭窄的犊牛的病理学特征。大体上，病变肾脏增大，肾盏扩张，并伴有输尿管狭窄。组织病理学上，观察到肾髓质中有多处间叶组织。这种间叶组织在苏木精和伊红染色中呈弱嗜酸性，在阿尔辛蓝染色中呈蓝色，在马松三色染色中呈淡蓝色，免疫组化染色显示波形蛋白和平滑肌肌动蛋白阳性，符合持续间叶组织。皮质肾单位的分化不同步，表现为不成熟的肾小球、不成熟的肾小管和小动脉增生。在伴有输尿管狭窄的输尿管壁中也观察到类似的持续间叶组织，输尿管肌层或平滑肌束排列紊乱。先天性输尿管狭窄似乎导致了输尿管梗阻和肾盂积水。这些病变可能代表了荷斯坦-弗里森牛犊中一种新的肾发育不良伴先天性输尿管狭窄的表型。
