Quantitative Clinical Pharmacology, Daiichi Sankyo, Inc., 211 Mt. Airy Road, Basking Ridge, New Jersey, 07920, USA.
AAPS J. 2022 Apr 29;24(3):59. doi: 10.1208/s12248-022-00714-0.
The food effects for orally administered drugs have been widely investigated and reviewed. In contrast, our knowledge of food effects for non-orally administered drugs is scarce. In this review paper, we did a literature survey to collect clinical food effect data for non-orally administered drugs. Our survey retrieved 18 drugs, including thirteen intravenously (IV), two subcutaneously (SC), one intradermally (ID), one pulmonary, and one rectally administered drug. The food effect data show that food intake can increase the absorption of SC and ID administered peptides and proteins with MW < 30 kDa by 30-50%. On the other hand, food intake can increase the elimination of IV and inhaled drugs with moderate and high hepatic extraction and reduce drug exposure by up to 35%. The food effect knowledge can be used to mitigate potential efficacy and safety risks of non-orally administered drugs.
口服药物的食物效应已得到广泛研究和综述。相比之下，我们对非口服药物的食物效应知之甚少。在这篇综述论文中，我们进行了文献调查，以收集非口服药物的临床食物效应数据。我们的调查共检索到 18 种药物，包括 13 种静脉（IV）、2 种皮下（SC）、1 种皮内（ID）、1 种肺内和 1 种直肠给药的药物。食物效应数据表明，进食可使 MW<30 kDa 的 SC 和 ID 给予的肽和蛋白质的吸收增加 30-50%。另一方面，进食可使中等和高肝提取的 IV 和吸入药物的消除增加，并使药物暴露减少高达 35%。食物效应知识可用于减轻非口服药物的潜在疗效和安全性风险。
