Haseki Training and Research Hospital, Department of Obstetrics and Gynecology, University of Health Science, Istanbul, Turkey.
Istanbul Training and Research Hospital, Department of Internal Medicine and Hematology, University of Health Science, Istanbul, Turkey.
J Perinat Med. 2022 May 2;50(7):887-895. doi: 10.1515/jpm-2021-0341. Print 2022 Sep 27.
Pregnancy carries a significant risk for coronavirus disease-2019 (COVID-19) due to natural immunosuppression. A previous study from our center has shown that the lactate dehydrogenase (LDH)/lymphocyte ratio (LLR) can be used in the early diagnosis of COVID-19 and predicting mortality. Based on this, we aimed to determine the effect of LLR on early detection of critical pregnant women and mortality in COVID-19.
The data of 145 patients who were admitted to our hospital between March and December 2020; diagnosed with COVID-19 and hospitalized, were retrospectively analyzed.
The median gestation period was 31 weeks (range: 5-41), 30.3% (n: 44) gave birth and 68.3% (n: 99) were pregnant. Median LLR was 0.13 (range: 0.04-0.70). The rate of cough (47% vs. 22.8%; p=0.003) was found to be high in patients with LLR>0.13. The patients were divided into subgroups. The proportion of patients without active complaints was higher in the Q1, followed by the Q4. The proportion of patients with an initial complaint of cough increased as LLR from Q1 to Q4, the distribution of other complaints did not differ between the quartiles.
The higher rate of cough in the group with high LLR indicates that it may be an important indicator of lung involvement during pregnancy. The highest rate of non-treatment follow-up in the lowest LLR group proved that the LLR value at the time of diagnosis can be used as an important clinical marker in
由于自然免疫抑制，妊娠使冠状病毒病 2019（COVID-19）的风险显著增加。我们中心的先前研究表明，乳酸脱氢酶（LDH）/淋巴细胞比率（LLR）可用于 COVID-19 的早期诊断和预测死亡率。基于此，我们旨在确定 LLR 对 COVID-19 中危孕妇早期检测和死亡率的影响。
回顾性分析了 2020 年 3 月至 12 月期间我院收治的 145 名 COVID-19 住院患者的数据。
中位妊娠周数为 31 周（范围：5-41），30.3%（n：44）分娩，68.3%（n：99）妊娠。中位 LLR 为 0.13（范围：0.04-0.70）。LRR>0.13 的患者咳嗽发生率（47% vs. 22.8%；p=0.003）较高。将患者分为亚组。在 Q1 中，无活动性主诉的患者比例较高，其次是 Q4。随着 LLR 从 Q1 到 Q4，初始主诉为咳嗽的患者比例增加，Q1 至 Q4 各四分位数组之间其他主诉的分布无差异。
高 LLR 组咳嗽发生率较高表明其可能是妊娠期肺部受累的重要指标。在 LLR 值最低的组中，无治疗随访的比例最高，这证明诊断时的 LLR 值可作为
