高压氧疗法对口腔微循环晚期放射损伤的影响。
The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation.
机构信息
Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Centre (UMC), AMC, University of Amsterdam, Amsterdam, the Netherlands.
Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands.
出版信息
Head Neck. 2022 Jul;44(7):1646-1654. doi: 10.1002/hed.27073. Epub 2022 Apr 29.
BACKGROUND
Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the in vivo effect of hyperbaric oxygen therapy (HBOT) on the microcirculation in irradiated oral tissue.
METHODS
Using a handheld microscope, the effect of HBOT on oral mucosal microcirculation parameters was measured in 34 previously irradiated HNCPs prior to HBOT and at 4 weeks and 6 months posttreatment.
RESULTS
A significant increase in mean buccal vessel density and decrease in buccal vessel diameter was found 6 months after HBOT compared to baseline, 22 ± 11 versus 25 ± 7 cpll/mm (p < 0.05) and 20 ± 4 versus 16 ± 5 μm (p < 0.05), respectively.
CONCLUSION
Our results indicate that oral microcirculation histopathology associated with irradiation is able to respond to HBOT by redirecting oral microcirculation parameters towards values consistent with healthy tissue.
背景
头颈部癌症（HNCPs）患者放疗后的迟发性副作用导致组织血管减少、愈合能力受损以及组织自发性破裂。本研究旨在探讨高压氧治疗（HBOT）对放射性口腔组织微循环的体内作用。
方法
使用手持式显微镜，在接受 HBOT 治疗前、治疗后 4 周和 6 个月，对 34 名既往接受过放疗的 HNCPs 的口腔黏膜微循环参数进行了 HBOT 的影响。
结果
与基线相比，HBOT 治疗 6 个月后，颊部血管密度的平均值显著增加，颊部血管直径显著减小，分别为 22±11 与 25±7 cpll/mm（p<0.05）和 20±4 与 16±5 μm（p<0.05）。
结论
我们的结果表明，与辐射相关的口腔微循环组织病理学能够通过将口腔微循环参数重新定向到与健康组织一致的值来对 HBOT 做出反应。
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