Mrosovsky N, Hallonquist J D
Brain Res. 1986 Dec 10;399(2):282-95. doi: 10.1016/0006-8993(86)91518-0.
The effects of lateral hypothalamic (LH) lesions were studied in golden-mantled ground squirrels, Spermophilus lateralis, a species of mammalian hibernator that displays endogenous circannual body weight cycles when kept in constant conditions. The lesions were made during the weight-gain phase. Evidence that the lesions were well placed included interruption of weight gain, transient aphagia, disrupted nest building, increased spillage of food crumbs and in some cases abnormal postures or movement. Despite these deficits most animals survived. Their body weights at the first postoperative peak of the cycle recovered either to within the control range (Experiment 1) or close to preoperative peak levels (Experiment 2). There was no evidence that the lesions lowered set points. The rapid recovery of weight and eating by ground squirrels given only dry rodent chow, after large lesions (1.5-2.5 mA, DC anodal, 15-25 s), contrasts with what is seen in rats following LH lesions.
对侧下丘脑（LH）损伤的影响在金背地松鼠（Spermophilus lateralis）中进行了研究，金背地松鼠是一种哺乳动物冬眠者，当处于恒定条件下时会表现出内源性的年度体重循环。损伤是在体重增加阶段进行的。损伤位置良好的证据包括体重增加中断、短暂性食欲不振、筑巢行为紊乱、食物碎屑溢出增加，以及在某些情况下出现异常姿势或运动。尽管存在这些缺陷，但大多数动物存活了下来。它们在术后第一个周期峰值时的体重恢复到了对照范围内（实验1）或接近术前峰值水平（实验2）。没有证据表明损伤降低了设定点。在大剂量损伤（1.5 - 2.5 mA，直流阳极，15 - 25秒）后，仅给予干鼠粮的地松鼠体重和进食的快速恢复，与LH损伤后的大鼠情况形成对比。
