Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, CEP: 50670-901, Brazil.
Laboratory of Microbiology and Immunology, Academic Center of Vitória (CAV), Federal University of Pernambuco (UFPE), Vitória de Santo Antão, Rua Do Alto Do Reservatório S/N, Bela Vista, Vitória de Santo Antão, Pernambuco, CEP: 55608-680, Brazil.
Curr Microbiol. 2022 Apr 30;79(6):175. doi: 10.1007/s00284-022-02875-9.
Antimicrobial resistance (AMR) represents a critical obstacle to public health worldwide, due to the high incidence of strains resistant to available antibiotic therapies. In recent years, there has been a significant increase in the prevalence of resistant epidemic strains, associated with this, public health authorities have been alarmed about a possible scenario of uncontrolled dissemination of these microorganisms and the difficulty in interrupting their transmission, as nosocomial pathogens with resistance profiles previously considered sporadic. They become frequent bacteria in the community. In addition, therapy for infections caused by these pathogens is based on broad-spectrum antibiotic therapy, which favors an increase in the tolerance of remaining bacterial cells and is commonly associated with a poor prognosis. In this review, we present the current status of epidemic strains of methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus (VRE), MDR Mycobacterium tuberculosis, extended-spectrum β-lactamase-producing Enterobacterales (ESBL), Klebsiella pneumoniae carbapenemase (KPC), and-New Delhi Metallo-beta-lactamase-producing Pseudomonas aeruginosa (NDM).
抗微生物药物耐药性（AMR）代表了全球公共卫生的一个重大障碍，因为存在大量对现有抗生素治疗方法具有耐药性的菌株。近年来，耐药性流行菌株的患病率显著增加，与此相关的是，公共卫生当局对这些微生物可能出现失控传播以及难以中断其传播的情况感到震惊，因为先前被认为是散发性的具有耐药谱的医院病原体成为社区中常见的细菌。此外，由这些病原体引起的感染的治疗基于广谱抗生素治疗，这有利于增加剩余细菌细胞的耐受性，并且通常与预后不良相关。在这篇综述中，我们介绍了耐甲氧西林金黄色葡萄球菌（MRSA）、万古霉素耐药肠球菌（VRE）、耐多药结核分枝杆菌、产超广谱β-内酰胺酶的肠杆菌科（ESBL）、产碳青霉烯酶肺炎克雷伯菌（KPC）和产新德里金属β-内酰胺酶的铜绿假单胞菌（NDM）等流行菌株的现状。
