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新型冠状病毒肺炎相关免疫复合物性肾小球肾炎的成功治疗:病例报告

Successful Treatment of COVID-19-Related Immune- Complex Glomerulonephritis, Case Report.

作者信息

Danis Ramazan, Gunay Emrah, Yuksel Enver, Kaya Seyhmus, Kılıc Jehat, Kacar Emrah, Senol Ayhan, Deniz Altıntas Derya, Yıldırım Mehmet Serdar

机构信息

University of Health Sciences, Gazi Yasargil Training and Research Hospital, Nephrology Department , Diyarbakir, Turkey.

出版信息

Iran J Kidney Dis. 2022 Mar;16(2):147-151.

Abstract

Acute kidney injury (AKI) , proteinuria in the nephrotic or subnephrotic range and hematuria might be seen in patients with coronavirus disease 2019 (COVID-19) infection. In this case study we present a 59 years old manwho was diagnosed with immune-complex glomerulonephritis after development of rapidly progressive kidney failure accompanied by pulmonary hemorrhage, 2 months after COVID-19 infection. The patient was hospitalised with the diagnosis of acute kidney injury and nephrotic syndrome. Hemodialysis was performed due to uremic symptoms. Cyclophosphamide, methylprednisolone and plasmapheresis were started. Pathologic examination of kidney biopsy revealed features compatible with immune complex-related acute glomerulonephritis. Cyclophosphamide and plasmapheresis were discontinued , and treatment with 1 mg/kg/day methylprednisolone was continued. Immune-complex glomerulonephritis can be seen following COVID-19 infection. İt is important to diagnose this disease entity as soon as possible . Steroidtherapy and other supportive modalities might be sufficient in the treatment.  DOI: 10.52547/ijkd.6527.

摘要

2019冠状病毒病(COVID-19)感染患者可能出现急性肾损伤(AKI)、肾病范围或亚肾病范围的蛋白尿以及血尿。在本病例研究中,我们介绍了一名59岁男性,他在COVID-19感染2个月后出现快速进展性肾衰竭并伴有肺出血,随后被诊断为免疫复合物性肾小球肾炎。该患者因急性肾损伤和肾病综合征入院。由于出现尿毒症症状,进行了血液透析。开始使用环磷酰胺、甲泼尼龙和血浆置换治疗。肾活检的病理检查显示与免疫复合物相关的急性肾小球肾炎相符的特征。停用环磷酰胺和血浆置换,继续使用1mg/kg/天的甲泼尼龙治疗。COVID-19感染后可出现免疫复合物性肾小球肾炎。尽早诊断这一疾病实体很重要。类固醇治疗和其他支持性治疗方式可能足以治疗该病。DOI: 10.52547/ijkd.6527

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