The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 343000, China.
The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 343000, China.
Biomed Pharmacother. 2022 Jun;150:113029. doi: 10.1016/j.biopha.2022.113029. Epub 2022 Apr 27.
Neuropathic pain is a common clinical symptom of various diseases, and it seriously affects the physical and mental health of patients. Owing to the complex pathological mechanism of neuropathic pain, clinical treatment of pain is challenging. Therefore, there is growing interest among researchers to explore potential therapeutic strategies for neuropathic pain. A large number of studies have shown that development of neuropathic pain is related to nerve conduction and related signaling molecules. P2X3 receptors (P2X3R) are ATP-dependent ion channels that participate in the transmission of neural information and related signaling pathways, sensitize the central nervous system, and play a key role in the development of neuropathic pain. In this paper, we summarized the structure and biological characteristics of the P2X3R gene and discussed the role of P2X3R in the nervous system. Moreover, we outlined the related pathological mechanisms of pain and described the relationship between P2X3R and chronic pain to provide valuable information for development of novel treatment strategies for pain.
神经病理性疼痛是多种疾病的常见临床症状，严重影响患者的身心健康。由于神经病理性疼痛的病理机制复杂，临床疼痛治疗具有挑战性。因此，研究人员越来越有兴趣探索治疗神经病理性疼痛的潜在治疗策略。大量研究表明，神经病理性疼痛的发展与神经传导和相关信号分子有关。P2X3 受体 (P2X3R) 是一种依赖于 ATP 的离子通道，参与神经信息的传递和相关信号通路，使中枢神经系统敏感化，在神经病理性疼痛的发展中起关键作用。本文总结了 P2X3R 基因的结构和生物学特性，并讨论了 P2X3R 在神经系统中的作用。此外，我们概述了疼痛的相关病理机制，并描述了 P2X3R 与慢性疼痛之间的关系，为开发疼痛的新型治疗策略提供了有价值的信息。
