Health and Environment Research Center, Tabriz university of Medical Sciences, Tabriz, Iran; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sci Total Environ. 2022 Sep 10;838(Pt 1):155536. doi: 10.1016/j.scitotenv.2022.155536. Epub 2022 Apr 27.
Exposure to airborne particulate matter (PM) can be considered as an important risk factor for human health. Some cytokines have been recognized as the biomarkers of exposure to air pollution. Experimental studies indicate that PM exposure could be associated with inflammation. Thus, the purpose of this study was to evaluate whether the exposure to air PM is associated with biomarkers of inflammation. The specific aim of this study was to determine the correlation between airborne PM levels and IL-6 and TNF-α as airway inflammation biomarkers among two groups of late adolescents in northwest of Iran. This study included 46 subjects, comprising 23 asthmatic subjects and 23 non-asthmatic persons. Environmental PM (PM, PM and PM) levels were measured in dust storm and non-dust storm days during both cold and warm seasons. Following the sampling of PM, Two pro-inflammatory cytokines of IL-6 and TNF-α in exhaled breath condensate (EBC) were also determined in the EBC samples via commercial ELISA kits. Daily mean ambient air PM, PM and PM concentrations during the dust storm days was 221.79, 93.13 and 25.52 μg m and in non-dusty days 48.37, 18.54 and 6.1 μg m, respectively. Biomarkers levels were significantly (p < 0.001) higher in asthmatic students compared to the non-asthmatic subjects. EBC cytokines levels were increased in dust storm days compared to the non-dusty days (p < 0.001) and were positively correlated with different size of ambient PM concentration. Dust storm conditions can increase the pro-inflammatory cytokines and cause adverse effects on pulmonary health and lung tissue damage.
空气中的颗粒物（PM）暴露可被视为人类健康的一个重要危险因素。一些细胞因子已被认为是暴露于空气污染的生物标志物。实验研究表明，PM 暴露可能与炎症有关。因此，本研究旨在评估空气中 PM 的暴露是否与炎症生物标志物有关。本研究的具体目的是确定伊朗西北部两组青少年中，空气中 PM 水平与白细胞介素 6（IL-6）和肿瘤坏死因子-α（TNF-α）作为气道炎症生物标志物之间的相关性。本研究纳入了 46 名受试者，包括 23 名哮喘患者和 23 名非哮喘患者。在寒冷和温暖季节的尘暴和非尘暴日，测量了环境 PM（PM、PM 和 PM）水平。在采样 PM 后，通过商业 ELISA 试剂盒还测定了呼出气冷凝液（EBC）中两种促炎细胞因子 IL-6 和 TNF-α的含量。尘暴日的每日平均环境空气 PM、PM 和 PM 浓度分别为 221.79、93.13 和 25.52μg/m，而在非尘暴日则分别为 48.37、18.54 和 6.1μg/m。与非哮喘患者相比，哮喘学生的生物标志物水平显著升高（p<0.001）。与非尘暴日相比，尘暴日 EBC 细胞因子水平升高（p<0.001），且与不同大小的环境 PM 浓度呈正相关。尘暴条件可增加促炎细胞因子，并对肺部健康和肺组织损伤产生不利影响。
