Jaafari Jalil, Naddafi Kazem, Yunesian Masud, Nabizadeh Ramin, Hassanvand Mohammad Sadegh, Shamsipour Mansour, Ghanbari Ghozikali Mohammad, Nazmara Shahrokh, Shamsollahi Hamid Reza, Yaghmaeian Kamyar
Research Center of Health and Environment, School of Health, Guilan University of Medical Sciences, Rasht, Iran; Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran.
Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Sci Total Environ. 2021 Mar 20;761:144503. doi: 10.1016/j.scitotenv.2020.144503. Epub 2020 Dec 14.
This study examined the association between particulate matter from anthropogenic and natural sources and inflammatory biomarkers, including hs-CRP, IL-6, sTNF-RII, and WBCs, in two groups of healthy young subjects. We followed up subjects of two panels (16 to 22 years old), including 22 subjects selected from the urban area (Tehran city) with high-level pollution background and 22 subjects selected from the rural area (Ahmadabad) with low-level pollution background. In each group, we collected 4 times blood samples in various air pollution conditions, In the subjects of the urban group, there was a substantial difference (p < 0.05) between inversion days and cold season control days, and between dust storm days and warm season control days for concentrations of hs-CRP, IL-6, and WBCs biomarkers. In the subjects of the rural group, a significant difference could be detected in the concentration of hs-CRP, IL-6, and WBCs biomarkers (p < 0.05) between inversion days and cold season control days, and between dust storm and warm control days. We found that the difference in concentrations of hs-CRP, IL-6, and WBCs biomarkers between dust storm days and warm control conditions in the rural group were higher than the difference in inversion and cold control conditions, which can be attributed to low background air pollution in the rural area. In the urban area, the health effect of anthropogenic sources of PM is higher than the dust storm condition, which can be attributed to the stronger effect of anthropogenic pollution effect.
本研究调查了两组健康年轻受试者中来自人为源和自然源的颗粒物与炎症生物标志物（包括超敏C反应蛋白、白细胞介素-6、可溶性肿瘤坏死因子受体II和白细胞）之间的关联。我们对两个小组（16至22岁）的受试者进行了随访，其中包括从污染水平高的市区（德黑兰市）选取的22名受试者以及从污染水平低的农村地区（艾哈迈达巴德）选取的22名受试者。在每组中，我们在不同空气污染条件下采集了4次血样。在城市组受试者中，超敏C反应蛋白、白细胞介素-6和白细胞生物标志物的浓度在逆温日与寒冷季节对照日之间以及沙尘暴日与温暖季节对照日之间存在显著差异（p<0.05）。在农村组受试者中，超敏C反应蛋白、白细胞介素-6和白细胞生物标志物的浓度在逆温日与寒冷季节对照日之间以及沙尘暴日与温暖对照日之间也能检测到显著差异（p<0.05）。我们发现，农村组沙尘暴日与温暖对照条件下超敏C反应蛋白、白细胞介素-6和白细胞生物标志物浓度的差异高于逆温与寒冷对照条件下的差异，这可归因于农村地区较低的背景空气污染。在城市地区，人为源颗粒物的健康影响高于沙尘暴条件，这可归因于人为污染效应更强。
