Ventura G J, Buzdar A U, Kau S, Lichtiger B, Hortobagyi G N
Cancer Treat Rep. 1987 Apr;71(4):411-3.
Nineteen patients with metastatic breast cancer refractory to conventional therapy were treated with plasma perfusion over 200 mg of staphylococcal Protein A immobilized on a silica matrix. Fever and chills (33%), pain at the site of tumor (18%), and dyspnea (16%) were the most frequent toxic effects encountered. Four patients (21%) developed a disseminated rash which necessitated cessation of treatment. Of 16 patients evaluable for response, one achieved a minor response of chest wall disease and two had no change in hepatic metastases for 4 and 5 months' duration. Potential mechanisms of antitumor effect are discussed.
19例对传统治疗难治的转移性乳腺癌患者接受了在固定于硅胶基质上的200毫克葡萄球菌A蛋白上进行血浆灌注治疗。最常出现的毒性反应是发热和寒战（33%）、肿瘤部位疼痛（18%）和呼吸困难（16%）。4例患者（21%）出现弥漫性皮疹，这使得治疗不得不中断。在可评估反应的16例患者中，1例患者胸壁疾病有轻微反应，2例患者肝转移灶在4个月和5个月期间无变化。文中讨论了抗肿瘤作用的潜在机制。
