血管紧张素 III 在大脑和外周中的作用。

Roles of Angiotensin III in the brain and periphery.

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD NIH-20892, USA.

出版信息

Peptides. 2022 Jul;153:170802. doi: 10.1016/j.peptides.2022.170802. Epub 2022 Apr 27.

DOI:10.1016/j.peptides.2022.170802

PMID:35489649

Abstract

Angiotensin (Ang) III, a biologically active peptide of the renin angiotensin system (RAS) is predominantly known for its central effects on blood pressure. Our understanding of the RAS has evolved from the simplified, classical RAS, a hormonal system regulating blood pressure to a complex system affecting numerous biological processes. Ang II, the main RAS peptide has been widely studied, and its deleterious effects when overexpressed is well-documented. However, other components of the RAS such as Ang III are not well studied. This review examines the molecular and biological actions of Ang III and provides insight into Ang III's potential role in metabolic diseases.

摘要

血管紧张素（Ang）III 是肾素血管紧张素系统（RAS）的一种生物活性肽，主要因其对血压的中枢作用而闻名。我们对 RAS 的理解已经从调节血压的简化经典 RAS 发展为影响众多生物过程的复杂系统。血管紧张素 II（Ang II）是 RAS 的主要肽，已被广泛研究，其过度表达的有害影响有充分的记录。然而，RAS 的其他成分，如 Ang III，研究得还不够充分。这篇综述检查了 Ang III 的分子和生物学作用，并深入探讨了 Ang III 在代谢性疾病中的潜在作用。